Quantitative Considerations for Pediatric Oncology Drug Discovery & Development

Due to the rapid and continuous physiological changes during growth and development, pediatric patients cannot be treated as “small adults.” These physiological and molecular differences include body composition (height and weight), organ function and size, receptor response (pathway, safety), and maturation of absorption, distribution, metabolism, and excretion (ADME) changes. In addition to ontogeny considerations, pediatric … Continued

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