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Banish hERGphobia: Using Systems Pharmacology to Assess Cardiac Safety

Is the era of “hERGphobia” finally coming to an end? 薬物性の心血管系副作用は、医薬品の市場撤退の主な原因の1つであり、医薬品添付文書における使用制限に関連する事項の1つでもあります。As a result, biopharmaceutical companies are keen to identify new drug candidates with a propensity to cause arrhythmias, or the heart to beat with … Continued

Personalized Toxicology: A New Paradigm for Chemical Risk Assessment

Historically, toxicity testing has been conducted by giving lab animals high doses of chemicals and observing them for adverse events. But quantifying the risks chemicals pose to humans based on animal studies is problematic as the chemical doses are often orders of magnitude higher than environmental levels. Moreover, this process is slow, expensive, and ethically … Continued

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