Matthew Harwood, Author at Certara

Beam Me Up, Scotty! Probing the Mechanisms of Transporter-mediated Drug Disposition

2018年7月27日

Over the last 15 years, the importance of drug transporters has become paramount for understanding drug absorption, distribution into tissues, and in particular, drug-drug interactions (DDIs). In vitro-in vivo extrapolation (IVIVE) is an approach to link in vitro systems to the human in vivo situation using algorithms and physiologically-based scaling factors. In this blog, I … Continued

The Next Horizons in Predicting Drug-drug Interactions

2016年3月23日

By Matthew Harwood

Physiologically-based pharmacokinetic (PBPK) modeling has arrived in prime time. This quantitative mechanistic framework, combining physiology with drug information and clinical trial design, has become an integral part of drug discovery and development. PBPK has also gained currency within industry and regulatory agencies. Its applications are numerous, including simulation of pre-clinical, healthy volunteer and special population … Continued

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Author: Matthew Harwood