The Certara Blog

Author: Thomas Polasek

Dr. Tom Polasek is Clinical Pharmacologist at Certara and SA Health in South Australia. His research interests include all aspects of clinical pharmacology with a focus on the clinical application of M&S approaches. He is the author or co-author of more than 100 peer-reviewed articles and conference presentations. Tom earned his BPharm (Hons) from the University of South Australia and his BSc, MD and PhD degrees from Flinders University.

Recent Posts

Using Virtual Twin™ Technology to Predict Drug Exposure in Individual Patients

Physiologically-based pharmacokinetics (PBPK) is a valuable resource to support decisions throughout drug development for sponsors and regulators. PBPK is used extensively to predict drug-drug interactions (DDIs), to inform dosing and clinical study design, to predict drug exposure, to predict variation in drug clearance, and to understand mechanisms of drug disposition. Virtual Twin technology, based on […]

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Using Virtual Twin™ Technology for Model-informed Precision Dosing

In a recent Expert Review of Clinical Pharmacology article, I assessed the status and future direction of precision dosing in clinical medicine.1 Model-informed precision dosing (MIPD) is a modeling and simulation (M&S) approach in healthcare that is used to predict the most effective and/or least toxic drug dose for a patient. MIPD could revolutionize healthcare […]

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