2022年SOT年次会合
Up to the Task? Quantitative Evaluation Criteria for Physiologically Based Pharmacokinetic (PBPK) Models
Frederic Bois
|サターラ
San Diego Convention Center Ballroom 6D
4751: Poster Board – P813: Use of Secondary Intelligence to Predict Postural Hypotension in Humans Using Alpha-1A Adrenoceptor Binding Data
Clare Gilmer
|Certara UK Limited
C. Gilmer1, M. Abbasi1, S. Andrews1, J. Craven1, G. Haslam1, M. Holbrook1, L. Hutchinson1, B. Islam1, E. Jo1, K. Lambert1, C. E. Pollard1, L. Rosenbrier Ribeiro2, J. Starkey1, and W. S. Redfern1. 1Certara UK Limited, Sheffield, United Kingdom; and 2R2 Pharmacology Limited, Manchester, United Kingdom. Sponsor: W. Redfern, Safety Pharmacology Society
4379: Poster Board – P333: A Simplified Rate Independent Measure of QT Prolongation in Primates Tested Using Body Temperature as the Positive Control Board no. P333
Marc Bailie
|INDS Inc.
D. Leishman1, M. Bailie2, N. Ether3, and A. Lauver3. 1Eli Lilly and Company, Indianapolis, IN; 2INDS Inc., Ann Arbor, MI; and 3Michigan State University, East Lansing, MI.
4387: Poster Board – P341: The Positive Control You Never Knew You Had in Every Primate QTc Study?
Derek Leishman
|Eli Lilly and Company
D. Leishman. Eli Lilly and Company, Indianapolis, IN. Sponsor: M. Bailie
389: Poster Board – P343: A Definitive Nonhuman Primate Study of Moxifloxacin Sized as a Clinical thorough QT (TQT) Study to Define the Operating Characteristics of More Conventionally Sized Nonclinical QTc Studies
Derek Leishman
|Eli Lilly and Company
D. Leishman1, D. Holdsworth2, K. Haist2, C. Poirier2, D. Best1, and B. Roche3. 1Eli Lilly and Company, Indianapolis, IN; 2Charles River, Mattawan, MI; and 3Charles River Laboratories Ashland LLC, Ashland, OH. Sponsor: M. Bailie
4805: Poster Board – P870: The “Best” QT Correction You Are Not Using? Board no. P870
Nicholas Ether
|Michigan State University
N. Ether1, M. Bailie2, D. Leishman3, and A. Lauver1. 1Michigan State University, East Lansing, MI; 2Integrated Nonclinical Development Solutions Inc., Ann Arbor, MI; and 3Eli Lilly and Company, Indianapolis, IN.