Visit Certara at the 10th Annual Neurodegenerative Drug Development Summit

Neurodegenerative diseases are complex and usually involve dysregulation in multiple biochemical pathways. Biosimulation is a proven technology to analyze these individual, integrated and combination challenges in silico. • Biosimulation can be used to simulate the interaction of different misfolded protein pathways with neuroinflammatory processes which is becoming increasingly important, not in the least by the identification of many microglia genes in large genetic studies. • Specifically, we discuss examples of how biosimulation couples the complex biological and pathological processes with the pharmacology of drugs in Alzheimer’s and Parkinson’s disease to evaluate the impact of mono and combination therapies in different patient population