炎症性腸疾患の病態形成における上皮障害の重要な役割を解明するための定量的システム薬理学モデル

In inflammatory bowel disease (IBD) patients, there is an imbalance between pro- and anti-inflammatory cytokines. When the epithelium is damaged, overproduction of pro-inflammatory cytokines causes inflammation, damaging the epithelium further, resulting in a severe state caused by chronic inflammation. While loss of epithelial barrier function (EBF) is known to play an important role in IBD, current treatment mainly targets the resulting chronic inflammation. In this project, we built a QSP model investigating the crucial role of a damaged EBF in IBD pathogenesis.