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2D-QSAR and HQSAR of the Inhibition of Calcineurin-NFAT Signaling by Blocking Protein-protein Interaction with N-(4-oxo-1(4H)-naphthalenylidene)benzenesulfonamide Analogs

The inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with N-(4-oxo-1(4H)-naphthalenylidene)benzenesulfonamide analogues was studied in order to obtain mechanistic information about the effects of structural modification and molecular design of immunomodulation agents. The study was carried out by quantitative structure-activity relationship (QSAR) analysis using 2D-QSAR and hologram QSAR (HQSAR) methods.
 

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