X-ray Structure of the Ternary MTX.NADPH Complex of the Anthrax Dihydrofolate Reductase: A Pharmacophore for Dual-site Inhibitor Design

For reasons of bioterrorism and drug resistance, it is imperative to identify and develop new molecular points of intervention against anthrax. Dihydrofolate reductase (DHFR) is a highly conserved enzyme and an established target in a number of species for a variety of chemotherapeutic programs. Recently, the crystal structure of Bacillus anthracis DHFR (baDHFR) in complex … Continued

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