Anesthetic Binding Sites for Etomidate and Propofol on a GABAA Receptor Model

Investigating the molecular basis of general anaesthetic activity at the GABA(A) ligand-gated ion channel is challenging due to the wide structural diversity among known general anaesthetics, and the lack of an experimental structure for the GABA(A) protein. In this molecular modelling study, two distinct binding cavities were identified within the ß(2) subunit of the transmembrane … Continued

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