Conversion from Twice- to Once-daily Tacrolimus in Pediatric Kidney Recipients: A Pharmacokinetic and Bioequivalence Study

The objectives of this study were to investigate pharmacokinetic and pharmacogenetic parameters during the conversion on a 1:1 (mg:mg) basis from a twice-daily (Prograf) to once-daily (Advagraf) tacrolimus formulation in pediatric kidney transplant recipients. Twenty-four-hour pharmacokinetic profiles were analyzed before and after conversion in 19 stable renal transplant recipients (age 7–19 years). Tacrolimus pharmacokinetic parameters [area … Continued

1 of 1
Back to top
Powered by Translations.com GlobalLink OneLink Software