Are you passionate about PBPK? まさに同感です

Certara’s Simcyp team is a global organisation focussed on using the Simcyp physiologically-based pharmacokinetic (PBPK) platform to influence decision-making on drug development programs from discovery to regulatory filing. Our PBPK consultants work with hundreds of clients to inform human PK prediction, drug-drug interaction assessment, special population predictions and biopharmaceutics strategy.

We are seeking highly motivated and talented PBPK modelling scientists and experts with a DMPK, PBPK and/or a biopharmaceutics modelling background who share our passion for using PBPK models to understand and impact drug discovery and development questions.

Join an internationally recognised, multidisciplinary company, providing:

  • Further development of your knowledge and skills
  • Unique and exciting mix of academic and commercial environments
  • Regular attendance at scientific meetings as part of our continuous education programme

We are growing! Certara has a range of roles and levels for PBPK consultants and scientists. Below are several roles in the Simcyp Team you may be interested in.

PBPK Consultant or Associate Consultant

The role involves contributing to and/or leading consultancy projects with clients in the Pharmaceutical Industry to develop PBPK models for particular projects of interest. Apply PBPK models in support of a number of applications including but not limited to the following:

  • DDI liability prediction
  • Food effect prediction
  • PK prediction in special populations
  • Biopharmaceutics/bioequivalence prediction
  • Large molecule PK prediction.

You will be expected to contribute to consultancy projects with supervision and will need to keep abreast of the latest scientific development in the area of PBPK and IVIVE to enable effective communication with colleagues, clients and the wider scientific community.

 

Apply now
PBPK Consultant or Associate Consultant
Senior Director of PBPK Consultancy

Senior Director of PBPK Consultancy

The role involves leading consultancy projects with clients in the Pharmaceutical Industry to develop PBPK models for particular projects of interest from DDI liability prediction to PK prediction in special populations as well as large molecule PK prediction.

This is an exciting opportunity where you will grow and mentor the PBPK consultancy group. You will have a high profile in the scientific community – you will continue to publish your work, give talks at scientific meetings and engage in scientific debate with clients.

You will engage with potential and existing clients on a regular basis and oversee work performed by others in your team, including reviewing modelling work, crafting regulatory responses, and developing modelling and simulation plans.

Apply now

Associate or Senior Principal Scientist

In this role, you will take part in development of mechanistic physiologically based pharmacokinetic (PBPK) or PK/PD models models concerning safety and efficacy of small and large molecules for various tissues and organs. You will undertake novel research projects to further expand the capabilities of the Simcyp Simulator, which requires attention to detail, good communication skills and the ability to liaise effectively with software developers.

In addition, you will be expected to provide ongoing customer support and education and training related to the use of the Simulators. We offer a unique and exciting mix of academic and commercial environments, which encourage regular attendance at scientific meetings.

Apply now
Associate or Senior Principal Scientist
Statistician Senior/Associate Principal Scientist

Statistician Senior/Associate Principal Scientist

In this role, you will take a leading role in further development of statistical methods and software applicable to mechanistic models concerning safety and efficacy of small and large molecules drugs. You should have in-depth knowledge of inference methods applicable to complex models, including Bayesian methods. Working knowledge of population pharmacokinetic (multi-level) modelling and pharmacometrics would be appreciated. Hands-on experience with mechanistic physiologically based pharmacokinetic (PBPK) or PK/PD models would also be advantageous.

You will join an internationally recognised, multidisciplinary research team, providing opportunities for further development of your knowledge and skills.

Apply now
Hannah Jones
Hannah Jones, PhD Senior Vice President, Head of PBPK Consulting Services

グローバル製薬企業において 20 年以上にわたって研究開発に携わっていました。特に、PBPK や PK/PD モデリングの分野で優れた実績を残しています。PBPK や PK/PD モデリング、DMPK に関連した 50 件以上の論文を発表しています。モデリング&シミュレーション手法の活用を通して医薬品研究開発プログラムに多くの貢献を果たしてきました。

Bio Pic MasoudJamei
Masoud Jamei, PhD Senior Vice President, Simcyp Research & Development

Simcyp の設計や開発、実装を担当する科学者とプログラマーチームを統括しています。in vitro-in vivo 外挿や PBPK/PD モデル、トップダウンアプローチである PopPK モデル解析手法の PBPK モデルへの応用など様々な分野に精通しています。

Bio Pic AliceKe
Alice Ke Zamek, PhD Senior Director of PBPK Consultancy

Alice is an expert in physiologically-based pharmacokinetic and popPK modeling and simulation. Her research interests center around the applications of PBPK and PK/PD modeling to predicting complex drug interactions and PK/PD in special populations. She has held research roles at the FDA and Eli Lilly.

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