Phoenix Modeling Language School (PML School)

PK/PD モデル構築に関する教育ウェビナー

Phoenix WinNonlin® では、薬物動態 (PK)・薬力学 (PD) モデルのプログラム記述に Phoenix Modeling Language (PML) を採用しています。ほとんどのモデル構造は Phoenix のグラフィカルユーザーインタフェース (GUI) において構築することが可能である一方、PML によるコーディングを必要とするモデル構造も多く存在します。

Phoenix における PK、PD および PK/PD モデルの構築方法を教育することを目的として、当社はインタラクティブな教育ウェビナーシリーズを開始しました。このウェビナーシリーズは「Phoenix Modeling Language School」と呼ばれています。このシリーズでは、静脈内投与 (IV)・経口投与 (PO)データの同時フィッティング・TMDD (Target-Mediated Drug Disposition)モデル・腸肝循環・腫瘍増殖抑制などの多様なシナリオを取り上げ、各種セッションを Phoenix のユーザーに対して無料で公開しています。

概要説明のチュートリアルの後、参加者による質疑応答および PML の機能に関する議論の時間が設けられています。質問はセッションの登録時に受け付けています。各セミナーの実施後、レッスンの対象となった PML テキストコードおよびプレゼンテーション資料は Certara Support Forum からダウンロード可能です。同様に、過去のウェビナーの録画ビデオは Certara Support Forum で視聴可能のため、サポートフォーラムに是非ご登録ください。
※ 全てのウェビナーは、英語のみで配信されます。

2018 PML School Schedule

Population PK Modeling and Virtual BE Trial Simulation for Formulation Optimization
Oct 11, 2018 | 10am EST
Presenter: Loan Pham, Camargo
NONMEM-NLME Comparisons
PD Categorical response analysis
Oct 25, 2018 | 10am EST
Presenter: Bernd Wendt
NONMEM-NLME Comparisons
PD time-to-event analysis
November 8, 2018 | 10am EST
Presenter: Bernd Wendt
NONMEM-NLME Comparisons
PD count analysis
December 13, 2018 | 10am EST
Presenter: Bernd Wendt

過去に実施された PML School セッション

Introduction & Nonlinear Clearance
Learn how to build custom PK and PK/PD models in Phoenix WinNonlin
Presenter: Dan Weiner
Metabolite Kinetics
Simultaneously model plasma data of a drug and metabolite following 5-minute infusion; metabolite clearance follows Michaelis-Menten kinetics
Presenter: Chris Mehl
Two-compartment Repeated Oral Dosing
Fit multiple dose kinetic and dynamic data sequentially
Presenter: Bernd Wendt
Multiple Absorption Routes via the Graphical Phoenix Model
PK modeling of a compound that is absorbed rapidly via the buccal route, and also by delayed absorption in the GI tract
Presenter: Chris Mehl
Simultaneous Fitting of Plasma and Urine Data
Fit IV data first then IV and PO data separately and simultaneously
Presenter: Bernd Wendt
Target-mediated Drug Disposition
Model circulating plasma target with a TMDD model
Presenter: Dan Weiner
Enterohepatic Recirculation
Model enterohepatic recirculation (EHC) after intravenous administration
Presenter: Bernd Wendt
One-compartment 1st and 0-order Input
Fit and discriminate between first and zero-order absorption models
Presenter: Chris Mehl
Allometry-Elementary/Complex Dedrick Plot
Simultaneously fit an allometric model to data from mouse, rat and man
Presenter: Dan Weiner
Turnover III: Nonlinear Disposition
Characterize turnover of an endogenous compound
Presenter: Bernd Wendt
Analysis and Comparison of Link, Turnover and Receptor Binding Models
Fit a link-, turnover- and receptor binding model to data
Presenter: Dan Weiner
Sigmoidal Concentration-response Models
Apply Gompertz, Weibull, Richards, Morgan-Mercer-Flodin, Hill and logistic models
Presenter: Chris Mehl
Analysis of a Tissue Growth/Kill Model
Analyze a tumor cell kill model after acute dosing
Presenter: Bernd Wendt
Modeling Inhibition of Enzyme Activity by Means of Turnover
Construction of a mechanistic turnover model
Presenter: Chris Mehl
Effect Compartment III: IV Infusion
Model response-time data with a link-model
Presenter: Bernd Wendt
Turnover Model 1: IV Bolus Dosing
Model Warfarin-PCA interaction
Presenter: Chris Mehl
Turnover Model 4: IV Infusions
Apply a turnover model to multiple IV dosing response data
Presenter: Bernd Wendt
Turnover Model 1: Repeated Dosing I
Apply a turnover model to repeated po dosing response data
Presenter: Chris Mehl
Dose-response-time Analysis I-IV
Analyze dose-response-time data with an instantenous effect model
Presenter: Bernd Wendt
Transduction Modeling: Assessment of Number of Transit Compartments
Analyze a transduction rate limited response time course
Presenter: Bernd Wendt
Minimal Physiologically-based Pharmacokinetic Model for Monoclonal Antibodies (mAbs)
Construct the model graphically and fit plasma data from mAbs
Presenter: Loan Pham
Target-mediated Drug Disposition (TMDD) Modeling Using the Quasi-equilibrium Assumption
Write a textual model according to Gibiansky (2008), fit and simulate mAb profiles
Presenter: Frank Striebel
Adaptive Simulations: Extending PML to Trial Simulations
A pre-clinical example to simulate a desired outcome
Presenter: Bernd Wendt
Introduction to NONMEM-NLME Comparisons
PK 1-compartment IV bolus model FOCE
Presenter: Bernd Wendt
NONMEM-2-NLME
PK 2-compartment multiple dose-IV bolus Plasma and Urine QRPEM/IMP
Presenter: Bernd Wendt
NONMEM-2-NLME
PK 2-compartment oral with Disease State covariate on V and CL
Presenter: Venkateswari Muthukrishnan
TMDD Model Translated from NONMEM (NM-TRAN) to Phoenix NLME (PML)
Presenter: Loan Pham, Camargo
NONMEM-2-NLME
Nonlinear elimination and model validation I: Bootstrap
Presenter: Bernd Wendt
NONMEM-2-NLME
Mixed absorption and model validation II: VPC
Presenter: Bernd Wendt
NONMEM-2-NLME
Running NONMEM and Phoenix NLME in the cloud
Presenter: Bernd Wendt
NONMEM-2-NLME
PD Emax inhibitory with baseline and shape factor
Presenter: Bernd Wendt
NONMEM-2-NLME
PD indirect response with IV bolus dosing
Presenter: Bernd Wendt
NONMEM-2-NLME
PKPD 1-compartment IV infusion—Emax with baseline, shape and effect
Presenter: Bernd Wendt

About Our Speakers

Webinar-3speaker-Wendt-Mehl-WeinerDr. Bernd Wendt has been teaching as a trainer at Certara and is a lecturer at the Ludwig-Maximilians-Universität (Munich) for more than 5 years, providing seminars in pharmacokinetics and molecular modeling. He is currently heading the global support group at Certara.

Christopher Mehl is the Customer Support Manager, and is a software trainer at Certara since 2003. He has conducted over 200 training courses with Pharsight desktop products such as Phoenix WinNonlin, IVIVC, NLME, PKS, and Trial Simulator. These include workshops at the US Food and Drug Administration, universities, customer sites, and courses open to the public.

Dr. Daniel Weiner is the co-author of Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, now in its 5th ed. Dr. Weiner is an Adjunct Associate Professor with Division of Pharmacotherapy and Experimental Therapeutics in the School of Pharmacy, University of North Carolina and is an Affiliate Professor of Pharmacometrics, Center for Translational Medicine in the School of Pharmacy at the University of Maryland. During his career he has provided PK/PD training to over 2,000 students.

NONMEM-NLME Comparisons: PD Categorical Response Analysis
Date: October 25, 2018
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NONMEM-NLME Comparisons: PD Time-to-event Analysis
Date: November 8, 2018
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NONMEM-NLME Comparisons: PD Count Analysis
Date: December 13, 2018
Register Now
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