Bottom-up Modeling and Simulation of Tacrolimus Clearance: Prospective Investigation of Blood Cell Distribution, Sex and CYP3A5 Expression as Covariates and Assessment of Study Power Publication Bottom-up Modeling and Simulation of Tacrolimus Clearance: Prospective Investigation of Blood Cell Distribution, Sex and CYP3A5 Expression as Covariates and Assessment of Study Power The objectives were to investigate the ability of population-based in vitro-in vivo extrapolation (IVIVE) to…webdev2013年12月1日
An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment Publication An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment Treprostinil diolamine (oral treprostinil) is a prostacyclin analogue under evaluation for the treatment for pulmonary…webdev2013年12月1日
Modeling of Pharmacokinetic Systems Using Stochastic Deconvolution Publication Modeling of Pharmacokinetic Systems Using Stochastic Deconvolution In environments where complete mechanistic knowledge of the system dynamics is not available, a synergy…webdev2013年12月1日
Differences in Cytochrome P450-mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically-based Pharmacokinetic Modeling Publication Differences in Cytochrome P450-mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically-based Pharmacokinetic Modeling International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH)…webdev2013年12月1日
Absence of Pharmacokinetic Drug-drug Interaction of Pertuzumab with Trastuzumab and Docetaxel Publication Absence of Pharmacokinetic Drug-drug Interaction of Pertuzumab with Trastuzumab and Docetaxel Pertuzumab is a novel antihuman epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody. Combined…webdev2013年11月24日
A Structure-guided Approach for Protein Pocket Modeling and Affinity Prediction Publication A Structure-guided Approach for Protein Pocket Modeling and Affinity Prediction Binding affinity prediction is frequently addressed using computational models constructed solely with molecular structure and…webdev2013年11月9日
Predicted Heart Rate Effect of Inhaled LABA PF-00610355 in Volunteers and COPD Patients Publication Predicted Heart Rate Effect of Inhaled LABA PF-00610355 in Volunteers and COPD Patients The aim of this study was to assess the cardiovascular effects of a new inhaled…webdev2013年11月1日
Prediction of Overall Survival or Progression Free Survival by Disease Control Rate at Week 8 Is Independent of Ethnicity: Western Versus Chinese Patients with First-line Non-small Cell Lung Cancer Treated with Chemotherapy with or without Bevacizumab Publication Prediction of Overall Survival or Progression Free Survival by Disease Control Rate at Week 8 Is Independent of Ethnicity: Western Versus Chinese Patients with First-line Non-small Cell Lung Cancer Treated with Chemotherapy with or without Bevacizumab Categorizations of best response observed at week 8 of first-line treatment in two studies of…webdev2013年10月22日
Effect of Meal and Antisecretory Agents on the Pharmacokinetics of Danoprevir/Ritonavir in Healthy Volunteers Publication Effect of Meal and Antisecretory Agents on the Pharmacokinetics of Danoprevir/Ritonavir in Healthy Volunteers webdev2013年10月10日
Influence of Chronic Hepatitis C Infection on Cytochrome P450 3A4 Activity Using Midazolam as an In Vivo Probe Substrate Publication Influence of Chronic Hepatitis C Infection on Cytochrome P450 3A4 Activity Using Midazolam as an In Vivo Probe Substrate webdev2013年10月1日