Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data Publication Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data This article reports an analysis that aims to quantify the effect of fingolimod, an oral…webdev2013年3月1日
Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox Publication Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox Although smallpox has been eradicated, the United States government considers it a "material threat" and…webdev2013年3月1日
Predicting Drug-drug Interactions: Application of Physiologically-based Pharmacokinetic Models Under a Systems Biology Approach Publication Predicting Drug-drug Interactions: Application of Physiologically-based Pharmacokinetic Models Under a Systems Biology Approach The development of in vitro-in vivo extrapolation (IVIVE), a 'bottom-up' approach, to predict pharmacokinetic parameters…webdev2013年3月1日
In Vitro to Human In Vivo Translation—Pharmacokinetics and Pharmacodynamics of Quinidine Publication In Vitro to Human In Vivo Translation—Pharmacokinetics and Pharmacodynamics of Quinidine The translational sciences aim to transfer results from basic research to the treatment of animals…webdev2013年3月1日
Application of Knockout Mouse Models to Investigate the Influence of FcγR on the Pharmacokinetics and Anti-platelet Effects of MWReg30, a Monoclonal Anti-GPIIb Antibody Publication Application of Knockout Mouse Models to Investigate the Influence of FcγR on the Pharmacokinetics and Anti-platelet Effects of MWReg30, a Monoclonal Anti-GPIIb Antibody This work evaluates the influence of FcγR on the pharmacokinetics and pharmacodynamics of a rat…webdev2013年2月28日
Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology Publication Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology The nerve growth factor (NGF) pathway is of great interest as a potential source of…webdev2013年2月21日
Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan? 論文 Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan? Systems pharmacology is an emerging approach that sets out to use quantitative concepts rooted in…webdev2013年2月20日
Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction with Physiologically-based Pharmacokinetic Simulations Publication Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction with Physiologically-based Pharmacokinetic Simulations BMS-690514, a selective inhibitor of the ErbB and vascular endothelial growth factor receptors, has shown…webdev2013年2月1日
Bioavailability of Intranasal vs. Rectal Diazepam Publication Bioavailability of Intranasal vs. Rectal Diazepam There remains an unmet medical need in the out-of-hospital management of seizure emergencies because older…webdev2013年2月1日
Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies Publication Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the…webdev2013年2月1日