Combining Drug-disease and Economic Modeling to Inform Drug Development Decisions Publication Combining Drug-disease and Economic Modeling to Inform Drug Development Decisions Drug-disease models and clinical trial simulations are increasingly being used to support trial design and…webdev2001年11月1日
A Population Pharmacokinetic/Pharmacodynamic Analysis of Repeated Measures Time-to-event Pharmacodynamic Responses: The Antiemetic Effect of Ondansetron Publication A Population Pharmacokinetic/Pharmacodynamic Analysis of Repeated Measures Time-to-event Pharmacodynamic Responses: The Antiemetic Effect of Ondansetron This paper presents and illustrates methodology for specifying, estimating, and evaluating a predictive model for…webdev1999年12月1日
In Vivo Indices of Enzyme Activity—The Effect of Renal Impairment on the Assessment of CYP2D6 Activity Publication In Vivo Indices of Enzyme Activity—The Effect of Renal Impairment on the Assessment of CYP2D6 Activity Urinary drug metabolite ratios and urinary recoveries of metabolites, have been used to assess specific…webdev1999年6月1日
The Determination of Drug Metabolizing Enzyme Activity In Vivo: Pharmacokinetics and Statistical Issues Publication The Determination of Drug Metabolizing Enzyme Activity In Vivo: Pharmacokinetics and Statistical Issues Probe substrates for various isoforms of cytochrome P450 and other drug-metabolizing enzymes are now widely…webdev1998年12月1日
Caffeine Metabolic Ratios as Markers of Enzyme Activity: A Theoretical Assessment Publication Caffeine Metabolic Ratios as Markers of Enzyme Activity: A Theoretical Assessment At least six urinary metabolite ratios of caffeine have been proposed as probes for in…webdev1996年4月1日