Relationship Between AUC and Volume of Distribution
A few days ago on the pharmacokinetics listserve PharmPK, the following question appeared: I’m having…
Nathan Teuscher2011年1月26日
Where Did the 80-125% Bioequivalence Criteria Come From?
Most people involved in clinical pharmacokinetics are familiar with the 80-125% criterion. This criterion is…
Certara2011年1月24日
Generics and Bioequivalence
As the debate about health care in the United States continues forward, the term “generic…
Nathan Teuscher2011年1月10日
What are Compartmental Models?
Learn about compartmental models and their importance in pharmacokinetics. Find out how they simplify drug…
Nathan Teuscher2011年1月5日
What are Drug-drug Interactions Anyway?
A current buzz phrase in pharmaceutical research right now is “drug-drug interaction” or simply “drug…
Nathan Teuscher2011年1月5日
Trial Designs—Non-inferiority vs. Superiority vs. Equivalence
The primary purpose of a clinical trial is to address a scientific hypothesis. To address…
Certara2011年1月1日
Assessment of Algorithms for Predicting Drug-drug Interactions Via Inhibition Mechanisms: Comparison of Dynamic and Static Models
The prediction of drug-drug interactions (DDIs) from in vitro data usually utilizes an average dosing…
Danielle Pillsbury2011年1月1日
The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain
ATP-binding cassette transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) have been shown to…
Danielle Pillsbury2011年1月1日
