The Difference Between Vd and Vss
There are many terms used to represent volume of distribution, but two common ones are…
Certara2011年3月31日
What is Shrinkage?
In 2007, Mats Karlsson and Radojka Savic published a perspective in Clinical Pharmacology & Therapeutics…
Nathan Teuscher2011年3月29日
Sources of Interindividual Variability in IVIVE of Clearance: An Investigation into the Prediction of Benzodiazepine Clearance Using a Mechanistic Population-based Pharmacokinetic Model
Prediction of metabolic clearance in extreme individuals rather than the 'average human' is becoming an…
Danielle Pillsbury2011年3月24日
Is a Monte Carlo Simulation an Exotic Drink?
The term “Monte Carlo simulation” is often used in the modeling and simulation literature with…
Nathan Teuscher2011年3月21日
What is WinNonlin?
A reader suggested that I write a similar post about WinNonlin. Great idea! Thank you!…
Nathan Teuscher2011年3月16日
What is the Difference Between Individual and Population PK?
Pharmacokinetic analysis is often broken into two areas … “PK” and “population PK”. Sometimes the…
Nathan Teuscher2011年3月14日
Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450
Reaction phenotyping using recombinant human cytochromes P450 (P450) has great utility in early discovery. However,…
Danielle Pillsbury2011年3月1日
Casopitant: In Vitro Data and Simcyp Simulation to Predict In Vivo Metabolic Interactions Involving Cytochrome P450 3A4
has previously been shown to be a potent and selective antagonist of the human neurokinin-1…
Danielle Pillsbury2011年3月1日
Modeling and Predicting Drug Pharmacokinetics in Patients with Renal Impairment
Current guidance issued by the US FDA to assess the impact of renal impairment on…
Danielle Pillsbury2011年3月1日
Resurgence in the Use of Physiologically-based Pharmacokinetic Models in Pediatric Clinical Pharmacology: Parallel Shift in Incorporating the Knowledge of Biological Elements and Increased Applicability to Drug Development and Clinical Practice
This study had two primary aims: (i) To describe an example of the development work…
Danielle Pillsbury2011年3月1日
