How Can PK/PD Analysis Add Value to Patient Care?
In May 2011, T.J. Smith and B.E. Hillner published an opinion piece in the New…
Certara2011年7月11日
What is Curve Stripping?
The process of curve stripping is used in both compartmental and non-compartmental analysis. Each pharmacokinetic…
Certara2011年7月6日
Pharmacokinetic-pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-induced Arthritis
The purpose of this study was to develop a pharmacokinetic-pharmacodynamic disease progression (PK/PD/DIS) model to…
Certara2011年7月1日
Clinical Tolerance and Toxicity of Intravenous Baclofen: A Pilot Study in a Canine Model
Assess safety and tolerance of intravenous (IV) baclofen using a dog model. Prospective pharmacokinetic study…
Certara2011年7月1日
Simulation of Clinical Drug-drug Interactions from Hepatocyte CYP3A4 Induction Data and Its Potential Utility in Trial Designs
Rifampin and carbamazepine have been recommended in the U.S. Food and Drug Administration draft drug…
Certara2011年7月1日
Metabolism of [D10]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration
Polycyclic aromatic hydrocarbons (PAHs) are believed to be among the causative agents for lung cancer…
Certara2011年7月1日
