Cassette Dosing: Advantages and Challenges
Cassette dosing is a technique primarily used in drug discovery efforts in non-clinical studies to…
Nathan Teuscher2013年12月16日
Anatomical, Physiological and Metabolic Changes with Gestational Age During Normal Pregnancy: A Database for Parameters Required in Physiologically-based Pharmacokinetic Modeling
Pregnancy is associated with considerable changes in the physiological, anatomical and biochemical attributes in women.…
Danielle Pillsbury2013年12月13日
What is GLP (Good Laboratory Practice)?
Good laboratory practice or GLP is a set of principles intended to assure the quality…
Certara2013年12月9日
Bottom-up Modeling and Simulation of Tacrolimus Clearance: Prospective Investigation of Blood Cell Distribution, Sex and CYP3A5 Expression as Covariates and Assessment of Study Power
The objectives were to investigate the ability of population-based in vitro-in vivo extrapolation (IVIVE) to…
Danielle Pillsbury2013年12月1日
An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment
Treprostinil diolamine (oral treprostinil) is a prostacyclin analogue under evaluation for the treatment for pulmonary…
Danielle Pillsbury2013年12月1日
Modeling of Pharmacokinetic Systems Using Stochastic Deconvolution
In environments where complete mechanistic knowledge of the system dynamics is not available, a synergy…
Danielle Pillsbury2013年12月1日
Differences in Cytochrome P450-mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically-based Pharmacokinetic Modeling
International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH)…
Danielle Pillsbury2013年12月1日
