Nonlinear PK: What Does That Mean?
You may come across a phrase like the following and wonder what it means: “……
Certara2013年2月17日
Calculating Urine PK Parameters
Pharmacokinetic analysis normally focuses on systemic exposure to a drug; however, much can be learned…
Certara2012年12月6日
Bioavailability
Discover bioavailability in pharmacokinetics, its types, the first-pass effect, and calculations. Explore tools for accurate…
Certara2012年11月4日
What to Do with Those BLQs!
BLQ values are like those pimples we used to get as teenagers. They…
Certara2011年4月6日
The Difference Between Vd and Vss
There are many terms used to represent volume of distribution, but two common ones are…
Certara2011年3月31日
Why Should You Evaluate Dose Proportionality?
Dose proportionality is a common phrase used pharmacokinetics. Early in the pre-clinical development process, we…
Certara2011年2月17日
Where Did the 80-125% Bioequivalence Criteria Come From?
Most people involved in clinical pharmacokinetics are familiar with the 80-125% criterion. This criterion is…
Certara2011年1月24日
Trial Designs—Non-inferiority vs. Superiority vs. Equivalence
The primary purpose of a clinical trial is to address a scientific hypothesis. To address…
Certara2011年1月1日
Understanding Volume of Distribution
One of the most misunderstood pharmacokinetic (PK) parameters is volume of distribution. First of all…
Certara2010年6月5日
