Publication Archives

Publication

Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information

We aimed to investigate the application of combined mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling…

webdev2014年8月1日

Publication

Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor

Dutogliptin is a selective dipeptidyl peptidase-4 inhibitor shown to be efficacious and safe in patients…

webdev2014年7月14日

Publication

Simulation of Monoclonal Antibody Pharmacokinetics in Humans Using a Minimal Physiologically-based Model

Compared to small chemical molecules, antibodies and Fc-containing derivatives (mAbs) have unique pharmacokinetic behavior characterized by…

webdev2014年7月9日

Publication

Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin

Typically, pharmacokinetic-pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in…

webdev2014年7月9日

Publication

Model of the Distribution of Diastolic Left Ventricular Posterior Wall Thickness in Healthy Adults and Its Impact on the Behavior of a String of Virtual Cardiomyocytes

Correlation of the thickness of the left ventricular posterior wall (LVPWd) with various parameters, including…

webdev2014年7月1日

Publication

A Re-evaluation and Validation of Ontogeny Functions for CYPs 1A2 and 3A4 Based on In Vivo Data

Current cytochrome P450 (CYP) 1A2 and 3A4 ontogeny profiles, which are derived mainly from in…

webdev2014年7月1日

論文

Animal Versus Human Oral Drug Bioavailability: Do They Correlate?

Oral bioavailability is a key consideration in development of drug products, and the use of preclinical species in predicting bioavailability in human has…

webdev2014年6月16日

論文

Quantitative Prediction of Formulation-specific Food Effects and Their Population Variability from In Vitro Data Using the Physiologically-based ADAM Model: A Case Study Using BCS/BDDCS Class II Drug Nifedipine.

Quantitative prediction of food effects (FE) upon drug pharmacokinetics, including population variability, in advance of human trials may help with trial design by optimizing…

webdev2014年6月16日

Publication

Conversion from Twice- to Once-daily Tacrolimus in Pediatric Kidney Recipients: A Pharmacokinetic and Bioequivalence Study

The objectives of this study were to investigate pharmacokinetic and pharmacogenetic parameters during the conversion…

webdev2014年6月1日

Publication

Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients

Objectives of this study were to develop a population pharmacokinetic (PopPK) model for tacrolimus in…

webdev2014年6月1日

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論文

Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information

Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor

Simulation of Monoclonal Antibody Pharmacokinetics in Humans Using a Minimal Physiologically-based Model

Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin

Model of the Distribution of Diastolic Left Ventricular Posterior Wall Thickness in Healthy Adults and Its Impact on the Behavior of a String of Virtual Cardiomyocytes

A Re-evaluation and Validation of Ontogeny Functions for CYPs 1A2 and 3A4 Based on In Vivo Data

Animal Versus Human Oral Drug Bioavailability: Do They Correlate?

Quantitative Prediction of Formulation-specific Food Effects and Their Population Variability from In Vitro Data Using the Physiologically-based ADAM Model: A Case Study Using BCS/BDDCS Class II Drug Nifedipine.

Conversion from Twice- to Once-daily Tacrolimus in Pediatric Kidney Recipients: A Pharmacokinetic and Bioequivalence Study

Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients

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