The ISoP Standards and Best Practices Committee
The mission of the International Society of Pharmacometrics (ISoP) Standards and Best Practices Committee is…
webdev2014年6月1日
Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients
Model-based meta-analysis of dose response is a sophisticated method to guide dose and regimen selection.…
webdev2014年5月21日
Improving the Assessment of Heart Toxicity for All New Drugs Through Translational Regulatory Science
Fourteen drugs have been removed from the market worldwide because they cause torsade de pointes.…
webdev2014年5月1日
Changes in Individual Drug-independent System Parameters during Virtual Pediatric Pharmacokinetic Trials: Introducing Time-varying Physiology into a Pediatric PBPK Model
Although both POPPK and physiologically based pharmacokinetic (PBPK) models can account for age and other covariates within…
webdev2014年5月1日
Evaluation of Tumor Size Response Metrics to Predict Survival in Oncology Clinical Trials
Model-based drug development in oncology is still lagging despite a good momentum in the clinical…
webdev2014年4月1日
Exploratory Modeling and Simulation to Support Development of Motesanib in Asian Patients with Non-small Cell Lung Cancer Based on MONET1 Study Results
The motesanib phase III MONET1 study failed to show improvement in overall survival (OS) in…
webdev2014年4月1日
Physiologically-based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction
Herb–drug interaction predictions remain challenging. Physiologically based pharmacokinetic (PBPK) modeling was used to improve prediction…
webdev2014年3月26日
Population Pharmacokinetics of Azithromycin in Whole Blood, Peripheral Blood Mononuclear Cells, and Polymorphonuclear Cells in Healthy Adults
Azithromycin's extensive distribution to proinflammatory cells, including peripheral blood mononuclear cells (PBMCs) and polymorphonuclear cells…
webdev2014年3月5日
Impact of Electrocardiographic Data Quality on Moxifloxacin Response in Thorough QT/QTc Studies
Thorough QT studies are typically conducted for drugs with systemic bioavailability and include a positive…
webdev2014年3月1日
