Publication Archives

Publication

Informing pregnancy dose via target-mediated drug disposition modeling and simulations for a recombinant human monoclonal antibody

The article titled "Informing pregnancy dose via target-mediated drug disposition modeling and simulations for a…

Danielle Pillsbury2024年11月4日

Publication

Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women

The article titled "Using PBPK modeling to supplement clinical data and support the safe and…

Danielle Pillsbury2024年10月30日

Publication

Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment

要旨：T cell interaction in the tumor microenvironment is a key component of immuno-oncology therapy.…

Renee Fisher2024年10月29日

Publication

早期フィージビリティ・アセスメント：早期の創薬意思決定に有用な情報を提供するために生物学的薬剤の投与を正確に予測する方法

Early Feasibility Assessment (EFA) can impact early drug discovery decisions such as determining feasibility of…

Renee Fisher2024年10月29日

Publication

Medicines in pregnancy: A clinical pharmacology extrapolation framework to address knowledge gaps

Danielle Pillsbury2024年10月16日

Publication

A close examination of BCRP’s role in lactation and methods for predicting drug distribution into milk

The article, authored by Caroline Sychterz, Hong Shen, Yueping Zhang, Michael Sinz, Amin Rostami-Hodjegan, Brian…

Danielle Pillsbury2024年9月18日

Publication

ISB 2001 trispecific T cell engagerは、強力な腫瘍細胞毒性を示し、多発性骨髄腫細胞の免疫回避機構を克服します。

Abstract Despite recent advances in immunotherapies targeting single tumor-associated antigens, patients with multiple myeloma eventually…

Renee Fisher2024年9月18日

Publication

Towards a Platform Quantitative Systems Pharmacology (QSP) Model for Preclinical to Clinical Translation of Antibody Drug Conjugates (ADCs)

Abstract A next generation multiscale quantitative systems pharmacology (QSP) model for antibody drug conjugates (ADCs)…

Renee Fisher2024年9月18日

Publication

A Next Generation Mathematical Model for the in vitro to Clinical Translation of T-cell Engagers

Abstract T-cell engager (TCE) molecules activate the immune system and direct it to kill tumor…

Renee Fisher2024年9月18日

Publication

Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions

Abstract Incorporating an early evaluation of dosing requirements is crucial for assessing the viability of…

Renee Fisher2024年9月18日

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論文

Informing pregnancy dose via target-mediated drug disposition modeling and simulations for a recombinant human monoclonal antibody

Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women

Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment

早期フィージビリティ・アセスメント：早期の創薬意思決定に有用な情報を提供するために生物学的薬剤の投与を正確に予測する方法

Medicines in pregnancy: A clinical pharmacology extrapolation framework to address knowledge gaps

A close examination of BCRP’s role in lactation and methods for predicting drug distribution into milk

ISB 2001 trispecific T cell engagerは、強力な腫瘍細胞毒性を示し、多発性骨髄腫細胞の免疫回避機構を克服します。

Towards a Platform Quantitative Systems Pharmacology (QSP) Model for Preclinical to Clinical Translation of Antibody Drug Conjugates (ADCs)

A Next Generation Mathematical Model for the in vitro to Clinical Translation of T-cell Engagers

Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions

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