Publication Archives

Publication

Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain

A significant barrier to realization of the full potential of clozapine as a therapeutic agent…

Certara2012年10月1日

Publication

In Vivo-formed Versus Preformed Metabolite Kinetics of Trans-resveratrol-3-sulfate and Trans-resveratrol-3-glucuronide

Metabolites in safety testing have gained a lot of attention recently. Regulatory agencies have suggested…

Certara2012年10月1日

Publication

Relationship Between Prenatal Exposure to Polychlorinated Biphenyls and Birth Weight: A Systematic Analysis of Published Epidemiological Studies Through a Standardization of Biomonitoring Data

Impact of prenatal PCB exposure on birth weight was investigated in various children cohorts and…

Certara2012年10月1日

Publication

Pharmacokinetic and Pharmacodynamic Analysis of Efavirenz Dose Reduction Using an In Vitro-In Vivo Extrapolation Model

The pharmacokinetics (PK) of efavirenz (EFV) is characterized by marked inter-patient variability that correlates with…

Certara2012年10月1日

Publication

Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

To date, there has been little investigation of the risk for drug-drug interactions involving monoclonal…

Certara2012年9月1日

Publication

Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation

Polycyclic aromatic hydrocarbons (PAHs) in cigarette smoke are among the most likely causes of lung…

Certara2012年9月1日

Publication

Armodafinil and Modafinil in Patients with Excessive Sleepiness Associated with Shift Work Disorder: A Pharmacokinetic and Pharmacodynamic Model for Predicting and Comparing Their Concentration-effect Relationships

Armodafinil, the longer lasting R-isomer of racemic modafinil, improves wakefulness in patients with excessive sleepiness…

Certara2012年9月1日

Publication

Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis

Lesion count observed on brain magnetic resonance imaging scan is a common end point in…

Certara2012年9月1日

Publication

Dose Correction for the Michaelis-Menten Approximation of the Target—Mediated Drug Disposition Model

The Michaelis-Menten (M-M) approximation of the target-mediated drug disposition (TMDD) pharmacokinetic (PK) model was derived…

Certara2012年8月23日

Publication

The Right Compound in the Right Assay at the Right Time: An Integrated Discovery DMPK Strategy

The high rate of attrition during drug development and its associated high research and development…

Certara2012年8月1日

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論文

Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain

In Vivo-formed Versus Preformed Metabolite Kinetics of Trans-resveratrol-3-sulfate and Trans-resveratrol-3-glucuronide

Relationship Between Prenatal Exposure to Polychlorinated Biphenyls and Birth Weight: A Systematic Analysis of Published Epidemiological Studies Through a Standardization of Biomonitoring Data

Pharmacokinetic and Pharmacodynamic Analysis of Efavirenz Dose Reduction Using an In Vitro-In Vivo Extrapolation Model

Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation

Armodafinil and Modafinil in Patients with Excessive Sleepiness Associated with Shift Work Disorder: A Pharmacokinetic and Pharmacodynamic Model for Predicting and Comparing Their Concentration-effect Relationships

Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis

Dose Correction for the Michaelis-Menten Approximation of the Target—Mediated Drug Disposition Model

The Right Compound in the Right Assay at the Right Time: An Integrated Discovery DMPK Strategy

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