Publication Archives

Publication

Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus

Sex differences in the clearance of substrates of Cytochrome P4503A (CYP3A4) have been reported frequently…

webdev2012年7月1日

Publication

Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics During Pregnancy: Achievements and Shortcomings

The physiological changes that occur in the maternal body and the placental-foetal unit during pregnancy…

webdev2012年7月1日

Publication

Prediction of Concentration-time Profile and Its Inter-individual Variability Following the Dermal Drug Absorption

Estimation of systemic exposure after absorption of any xenobiotic from the skin is very important…

webdev2012年7月1日

Publication

Physiologically-based Pharmacokinetics Joined with In Vitro-In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

Classic pharmacokinetics (PK) rarely takes into account the full knowledge of physiology and biology of…

webdev2012年7月1日

Publication

A Mechanistic Pharmacokinetic Model to Assess Modified Oral Drug Bioavailability Post Bariatric Surgery in Morbidly Obese Patients: Interplay Between CYP3A Gut Wall Metabolism, Permeability, and Dissolution

Due to the multi-factorial physiological implications of surgery, attempts to explain trends in oral bioavailability following bariatric…

webdev2012年6月11日

Publication

Pharmacokinetics, Lymph Node Uptake and Mechanistic PK Model of Near Infrared Dye Labeled Bevacizumab After IV and SC Administration in Mice

Our objective was to determine the pharmacokinetics, bioavailability and lymph node uptake of the monoclonal…

webdev2012年6月1日

Publication

Prediction of Drug Clearance in a Smoking Population: Modeling the Impact of Variable Cigarette Consumption on the Induction of CYP1A2

The objective of this study was to derive estimates of CYP1A2 abundance as a function…

webdev2012年6月1日

Publication

Target-mediated Pharmacokinetic and Pharmacodynamic Model of Exendin-4 in Rats, Monkeys, and Humans

A mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) model was developed for exendin-4 to account for receptor-mediated endocytosis via…

webdev2012年5月1日

Publication

Noninvasive Real-time Fluorescence Imaging of the Lymphatic Uptake of BSA-IRDye 680 Conjugate Administered Subcutaneously in Mice

The goal of our studies was to determine lymphatic uptake of bovine serum albumin (BSA)…

webdev2012年5月1日

Publication

Modeling and Simulation of Edoxaban Exposure and Response Relationships in Patients with Atrial Fibrillation

Edoxaban is a novel, orally available, highly specific direct inhibitor of factor Xa and is…

webdev2012年5月1日

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論文

Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus

Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics During Pregnancy: Achievements and Shortcomings

Prediction of Concentration-time Profile and Its Inter-individual Variability Following the Dermal Drug Absorption

Physiologically-based Pharmacokinetics Joined with In Vitro-In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

A Mechanistic Pharmacokinetic Model to Assess Modified Oral Drug Bioavailability Post Bariatric Surgery in Morbidly Obese Patients: Interplay Between CYP3A Gut Wall Metabolism, Permeability, and Dissolution

Pharmacokinetics, Lymph Node Uptake and Mechanistic PK Model of Near Infrared Dye Labeled Bevacizumab After IV and SC Administration in Mice

Prediction of Drug Clearance in a Smoking Population: Modeling the Impact of Variable Cigarette Consumption on the Induction of CYP1A2

Target-mediated Pharmacokinetic and Pharmacodynamic Model of Exendin-4 in Rats, Monkeys, and Humans

Noninvasive Real-time Fluorescence Imaging of the Lymphatic Uptake of BSA-IRDye 680 Conjugate Administered Subcutaneously in Mice

Modeling and Simulation of Edoxaban Exposure and Response Relationships in Patients with Atrial Fibrillation

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