Publication Archives

Publication

Exposure-response Relationship of AMG 386 in Combination with Weekly Paclitaxel in Recurrent Ovarian Cancer and Its Implication for Dose Selection

The purpose of this study was to characterize exposure–response relationships of AMG 386 in a…

Certara2012年1月1日

Publication

Pre-clinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics

The preclinical absorption, distribution, metabolism, and excretion (ADME) properties of Pracinostat -1H-benzimidazol-5-yl]-N-hydroxyarylamide hydrochloride; SB939], an…

Certara2011年12月1日

Publication

Influence of Mild and Moderate Hepatic Impairment on Axitinib Pharmacokinetics

To evaluate the effects of hepatic impairment on the pharmacokinetics and safety of a single,…

Certara2011年12月1日

Publication

Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans

The pharmacokinetics of ibuprofen were studied under microgravity (µG) conditions and compared with those at…

Certara2011年12月1日

Publication

Population Pharmacokinetic-pharmacodynamic-disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-induced Arthritis

A population pharmacokinetic-pharmacodynamic-disease progression (PK/PD/DIS) model was developed to characterize the effects of anakinra in…

Certara2011年12月1日

Publication

Model-based Meta-analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond

High development cost, low development success, cost-disciplined health-care policies, and intense competition demand an efficient…

Certara2011年12月1日

Publication

Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose-response Meta-analysis

Information on the comparative effectiveness of drugs is crucial for drug development decisions, in addition…

Certara2011年12月1日

Publication

A Dose-response Meta-analysis for Quantifying Relative Efficacy of Biologics in Rheumatoid Arthritis

We present a dose-response meta-analysis to quantify relative efficacy of biologic disease-modifying antirheumatic drugs (DMARDs)…

Certara2011年12月1日

Publication

Application of a Systems Approach to the Bottom-up Assessment of Pharmacokinetics in Obese Patients: Expected Variations in Clearance

The maintenance dose of a drug is dependent on drug clearance, and thus any biochemical…

Certara2011年12月1日

Publication

Reducing Systems Biology to Practice in Pharmaceutical Company Research: Selected Case Studies

Reviews of the productivity of the pharmaceutical industry have concluded that the current business model…

Certara2011年11月18日

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論文

Exposure-response Relationship of AMG 386 in Combination with Weekly Paclitaxel in Recurrent Ovarian Cancer and Its Implication for Dose Selection

Pre-clinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics

Influence of Mild and Moderate Hepatic Impairment on Axitinib Pharmacokinetics

Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans

Population Pharmacokinetic-pharmacodynamic-disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-induced Arthritis

Model-based Meta-analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond

Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose-response Meta-analysis

A Dose-response Meta-analysis for Quantifying Relative Efficacy of Biologics in Rheumatoid Arthritis

Application of a Systems Approach to the Bottom-up Assessment of Pharmacokinetics in Obese Patients: Expected Variations in Clearance

Reducing Systems Biology to Practice in Pharmaceutical Company Research: Selected Case Studies

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