Modelling Approaches to Dose Estimation in Children
Most of the drugs on the market are originally developed for adults and dosage selection…
Certara2005年6月1日
Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion, and Toxicity
It is widely recognized that either predicting or determining the absorption, distribution, metabolism, excretion and…
Certara2005年4月1日
Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials
Devices for neuromuscular electrical stimulation (NMES) are increasingly used by individuals without specific injuries and…
Certara2005年1月1日
Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients
Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly…
Certara2005年1月1日
Pharmacokinetics of Dibutylphthalate in Pregnant Rats
Dibutylphthalate (DBP) can cause adverse effects on the developing male reproductive tract when administered late…
Certara2004年12月1日
In Silico Simulations to Assess the In Vivo Consequences of In Vitro Metabolic Drug-drug Interactions
Recently, metabolic drug-drug interactions (M-DDI) have raised some high-profile problems in drug development resulting in restricted use, withdrawal…
Certara2004年12月1日
Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH
Drug/metabolite ratios (MRs) are used as in vivo markers of enzyme activity. The ratios are…
Certara2004年12月1日
Predicting the Clearance of CYP2C9 Substrates
Recently, Andersson et al. (2004) reported that quantitative predictions of hepatic clearance from in vitro…
Certara2004年12月1日
Cytochrome P450 3A Expression and Activity in the Human Small Intestine
Recently, von Richter et al measured the content of cytochrome P450 (CYP) 3A in paired…
Certara2004年10月1日
Pharmacogenetics—Expectations and Reality
Thirty years have passed since Mike Rawlins, the current chairman of the National Institute for…
Certara2004年7月1日
