Guide to development of compound files for PBPK modeling in the Simcyp population-based simulator
The Simcyp Simulator is a software platform for population physiologically-based pharmacokinetic (PBPK) modeling and simulation.…
Certara2024年2月23日
The interaction of core modules as a basis for elucidating network behavior determining Parkinson’s disease pathogenesis
It is well-established that misfolded alpha-synuclein (alpha-syn) is a histopathological marker of Parkinson's disease. Given…
Certara2024年2月14日
Treatment patterns of patients with HR+/HER2- metastatic breast cancer receiving CDK4/6 inhibitor-based regimens: a cohort study in the French nationwide healthcare database
To assess real-world treatment patterns in patients diagnosed with hormone receptor positive (HR+), human epidermal…
Certara2024年1月17日
Real-world application of PBPK in drug discovery
The utility of PBPK models in support of drug development has been well documented. During…
Certara2024年1月11日
Physiologically Based Pharmacokinetic modelling of drugs in pregnancy: A mini-review on availability and limitations
This mini-review provides a concise and comprehensive overview of the pregnancy PBPK field and identify…
Certara2024年1月3日
A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy
This comprehensive review exposes gaps in current knowledge of phase II enzyme and drug transporter…
Certara2024年1月3日
Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy
For drugs highly bound to plasma proteins, changes in concentrations of free drug may have…
Certara2024年1月3日
Incorporating Pragmatic Elements in Study Designs to Enhance Oncology Randomized Clinical Trials
A FRIENDS OF CANCER RESEARCH WHITE PAPER The article explores the complex landscape of determining…
Certara2023年12月19日
Model-informed target identification and validation through combining quantitative systems pharmacology with network-based analysis
Authors: Vijayalakshmi Chelliah, Piet H. van der Graaf One of the main areas where quantitative…
Certara2023年11月28日
