Publication Archives

Publication

Physiologically Based Pharmacokinetic modelling of drugs in pregnancy: A mini-review on availability and limitations

This mini-review provides a concise and comprehensive overview of the pregnancy PBPK field and identify…

Jim Gallagher2024年1月3日

Publication

A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy

This comprehensive review exposes gaps in current knowledge of phase II enzyme and drug transporter…

Jim Gallagher2024年1月3日

Publication

Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy

For drugs highly bound to plasma proteins, changes in concentrations of free drug may have…

Jim Gallagher2024年1月3日

Publication

Incorporating Pragmatic Elements in Study Designs to Enhance Oncology Randomized Clinical Trials

A FRIENDS OF CANCER RESEARCH WHITE PAPER The article explores the complex landscape of determining…

Jim Gallagher2023年12月19日

Publication

Model-informed target identification and validation through combining quantitative systems pharmacology with network-based analysis

Authors: Vijayalakshmi Chelliah, Piet H. van der Graaf One of the main areas where quantitative…

Jim Gallagher2023年11月28日

Publication

Creation of novel sensitive probe substrate and moderate inhibitor models for a comprehensive prediction of CYP2C8 interactions for tucatinib

Authors: Ian E. Templeton, Karen Rowland-Yeo, Hannah M. Jones, Christopher J. Endres, Ariel R. Topletz-Erickson, Hao Sun, Anthony J. Lee A…

Jim Gallagher2023年11月28日

Publication

A quantitative clinical pharmacology-based framework for model-informed vaccine development

Historically, vaccine development and dose optimization have followed mostly empirical approaches without clinical pharmacology and…

Jim Gallagher2023年11月20日

Publication

No Recipe for Quantitative Systems Pharmacology Model Validation, but a Balancing Act Between Risk and Cost

Quantitative systems pharmacology (QSP) models generate predictions by formalizing biological understanding and integrating multiscale data,…

Jim Gallagher2023年11月16日

Publication

人工知能アプリケーションに対する規制の取り組み：レギュラトリーライティングへの影響

メディカルライティング | Volume 32, Issue 3 - Artificial Intelligence and Machine LearningAuthor: Anjana Bose…

Danielle Pillsbury2023年10月11日

Publication

Analysis of clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration using a quantitative systems pharmacology model

Hugo Geerts, Silke Bergeler, Mike Walker, Piet van der Graaf, Jean-Philippe Courade. Sci Rep. 2023…

Danielle Pillsbury2023年10月5日

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論文

Physiologically Based Pharmacokinetic modelling of drugs in pregnancy: A mini-review on availability and limitations

A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy

Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy

Incorporating Pragmatic Elements in Study Designs to Enhance Oncology Randomized Clinical Trials

Model-informed target identification and validation through combining quantitative systems pharmacology with network-based analysis

Creation of novel sensitive probe substrate and moderate inhibitor models for a comprehensive prediction of CYP2C8 interactions for tucatinib

A quantitative clinical pharmacology-based framework for model-informed vaccine development

No Recipe for Quantitative Systems Pharmacology Model Validation, but a Balancing Act Between Risk and Cost

人工知能アプリケーションに対する規制の取り組み：レギュラトリーライティングへの影響

Analysis of clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration using a quantitative systems pharmacology model

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