Publication Archives

Publication

Creation of novel sensitive probe substrate and moderate inhibitor models for a comprehensive prediction of CYP2C8 interactions for tucatinib

Authors: Ian E. Templeton, Karen Rowland-Yeo, Hannah M. Jones, Christopher J. Endres, Ariel R. Topletz-Erickson, Hao Sun, Anthony J. Lee A…

Certara2023年11月28日

Publication

A quantitative clinical pharmacology-based framework for model-informed vaccine development

Historically, vaccine development and dose optimization have followed mostly empirical approaches without clinical pharmacology and…

Certara2023年11月20日

Publication

No Recipe for Quantitative Systems Pharmacology Model Validation, but a Balancing Act Between Risk and Cost

Quantitative systems pharmacology (QSP) models generate predictions by formalizing biological understanding and integrating multiscale data,…

Certara2023年11月16日

Publication

人工知能アプリケーションに対する規制の取り組み：レギュラトリーライティングへの影響

メディカルライティング | Volume 32, Issue 3 - Artificial Intelligence and Machine LearningAuthor: Anjana Bose…

Certara2023年10月11日

Publication

Analysis of clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration using a quantitative systems pharmacology model

Hugo Geerts, Silke Bergeler, Mike Walker, Piet van der Graaf, Jean-Philippe Courade. Sci Rep. 2023…

Certara2023年10月5日

Publication

Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS/MS proteomics using a QconCAT technique

Characterising the small intestine absorptive membrane is essential to enable prediction of the systemic exposure…

Certara2023年8月29日

Publication

Development and Verification of a Japanese Pediatric Physiologically Based Pharmacokinetic Model with Emphasis on Drugs Eliminated by Cytochrome P450 or Renal Excretion

Physiologically based pharmacokinetic (PBPK) models are useful in bridging drug exposure in different ethnic groups,…

Certara2023年8月21日

Publication

Development and application of a PBPK modeling strategy to support antimalarial drug development

As part of a collaboration between Medicines for Malaria Venture (MMV), Certara UK and Monash…

Certara2023年8月18日

Publication

Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases

Successful clinical development of new therapeutic interventions is notoriously difficult, especially in neurodegenerative diseases, where…

Certara2023年8月15日

Publication

Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling

While the concept of ‘Virtual Bioequivalence’ (VBE) using a combination of modelling, in vitro tests and integration…

Certara2023年7月21日

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論文

Creation of novel sensitive probe substrate and moderate inhibitor models for a comprehensive prediction of CYP2C8 interactions for tucatinib

A quantitative clinical pharmacology-based framework for model-informed vaccine development

No Recipe for Quantitative Systems Pharmacology Model Validation, but a Balancing Act Between Risk and Cost

人工知能アプリケーションに対する規制の取り組み：レギュラトリーライティングへの影響

Analysis of clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration using a quantitative systems pharmacology model

Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS/MS proteomics using a QconCAT technique

Development and Verification of a Japanese Pediatric Physiologically Based Pharmacokinetic Model with Emphasis on Drugs Eliminated by Cytochrome P450 or Renal Excretion

Development and application of a PBPK modeling strategy to support antimalarial drug development

Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases

Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling

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