Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy
Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in…
Jieun Choe2020年10月12日
Enabling Warp Speed Using the Hypervelocity Innovation Model: A Blue Print for Drug Development in Pandemics
Pharmaceutical R&D is organized around prioritized investments, delivering on assets with the greatest return of…
Jieun Choe2020年9月28日
Clinical trials of disease stages in COVID 19: complicated and often misinterpreted
As of 2020年7月28日, 1840 clinical trials were registered globally, with 1001 clinical trials…
Jieun Choe2020年8月22日
Accelerating Clinical Evaluation of Repurposed Combination Therapies for COVID-19
As the global COVID-19 pandemic continues, unabated and clinical trials demonstrate limited effective pharmaceutical interventions,…
Jieun Choe2020年8月22日
Quantitative Systems Pharmacology approaches for immuno‐oncology: adding virtual patients to the development paradigm
Drug development in oncology commonly exploits the tools of molecular biology to gain therapeutic benefit…
Jieun Choe2020年7月26日
Model‐Informed Drug Repurposing: Viral Kinetic Modeling to Prioritize Rational Drug Combinations for COVID‐19
We hypothesized that viral kinetic modeling could be helpful to prioritize rational drug combinations for…
Jieun Choe2020年7月26日
Salvaging CNS Clinical Trials Halted Due to COVID‐19
The coronavirus disease 2019 (COVID‐19) pandemic has halted many ongoing central nervous system (CNS) clinical…
Jieun Choe2020年7月15日
Mechanistic quantitative pharmacology strategies for the early clinical development of bispecific antibodies in oncology
Bispecific antibodies (bsAbs) have become an integral component of the therapeutic research strategy to treat…
Jieun Choe2020年7月14日
