Conditional activation of IL-12 through a Fibronectin-EDB dependent switch gate
See how QSP modeling guided the design of a reversible antibody switch that unmasks IL-12…
Certara2026年7月24日
A novel mathematical framework to predict in vivo bispecific GTX-B001 binding in skin, and translation to humans
See how quantitative pharmacology and PBPK modeling supported first in human dose selection for a…
Certara2026年7月20日
Patient-Specific Determinants of Response to BCMA- and GPRC5D-Targeted CAR T-Cell Therapy in Multiple Myeloma: A QSP Analysis of Clinical Trial and Real-World Data
QSP modeling reveals patient-specific factors driving CAR T-cell response and relapse in multiple myeloma, with…
Certara2026年7月20日
Expert Q&A: Identify Winning Biotherapeutics in Early Discovery
Watch this on-demand Q&A on using mechanistic modeling to assess feasibility and prioritize biotherapeutic candidates…
Certara2026年7月17日
Integrating Endogenous Ligand Competition into a Mechanistic Whole-Body PBPK Model of Therapeutic Monoclonal Antibodies
Discover how endogenous ligand competition was incorporated into a whole-body PBPK model to improve prediction…
Certara2026年6月23日
Application of IO Simulator in Immuno-Oncology Combination Therapy: A Small Cell Lung Cancer Case Study
Learn how Certara's IO Simulator was used to predict efficacy, cytokine release syndrome risk, and…
Certara2026年6月23日
Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients
See how a QSP model guided efficacy-proximal FIH dosing for ISB 2001 in the TRIgnite-1…
Certara2026年6月4日
Applying AI-Driven Biosimulation to Drug Discovery
Certara President Leif Pedersen explains how PBPK and QSP modeling, proven across 125+ FDA-approved drugs,…
Certara2026年6月2日
Review: application and opportunities for machine learning and artificial intelligence in preclinical immunogenicity risk assessment
This review explores how artificial intelligence (AI), machine learning (ML), and quantitative systems pharmacology (QSP)…
Certara2026年6月2日
