Model-based Meta-analysis: An Innovative Methodology Comes of Age
MBMA integrates internal and external drug development data to inform proprietary commercial and R&D decisions.…
webdev2016年7月14日
Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9
RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low…
webdev2015年3月31日
The Effect of Plasmapheresis on Blood Pressure in Voluntary Plasma Donors
Donor plasmapheresis involves the removal of a weight-adjusted volume of plasma and the return of…
webdev2015年1月1日
Lack of Angiopoietin-like-2 Expression Limits the Metabolic Stress Induced by a High-fat Diet and Maintains Endothelial Function in Mice
Angiopoietin-like-2 (angptl2) is produced by several cell types including endothelial cells, adipocytes and macrophages, and…
webdev2014年8月15日
An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment
Treprostinil diolamine (oral treprostinil) is a prostacyclin analogue under evaluation for the treatment for pulmonary…
webdev2013年12月1日
Predicted Heart Rate Effect of Inhaled LABA PF-00610355 in Volunteers and COPD Patients
The aim of this study was to assess the cardiovascular effects of a new inhaled…
webdev2013年11月1日
Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide
CS-8635, a fixed-dose triple combination of olmesartan, amlodipine, and hydrochlorothiazide, was developed to address the…
webdev2013年4月1日
Characterization of Exposure Versus Response of Edoxaban in Patients Undergoing Total Hip Replacement Surgery
Edoxaban is an oral direct factor Xa inhibitor approved for the prevention of venous thromboembolism…
webdev2012年11月1日
