Siponimod for Patients with Relapsing-remitting Multiple Sclerosis (BOLD): An Adaptive, Dose-ranging, Randomized, Phase 2 Study Publication Siponimod for Patients with Relapsing-remitting Multiple Sclerosis (BOLD): An Adaptive, Dose-ranging, Randomized, Phase 2 Study Siponimod is an oral selective modulator of sphingosine 1-phosphate receptor types 1 and type 5,…webdev2013年9月1日
Using Historical Control Information for the Design and Analysis of Clinical Trials with Overdispersed Count Data Publication Using Historical Control Information for the Design and Analysis of Clinical Trials with Overdispersed Count Data Results from clinical trials are never interpreted in isolation. Previous studies in a similar setting…webdev2013年9月1日
A Pilot Study Assessing the Bioavailability and Pharmacokinetics of Diazepam After Intranasal and Intravenous Administration in Healthy Volunteers Publication A Pilot Study Assessing the Bioavailability and Pharmacokinetics of Diazepam After Intranasal and Intravenous Administration in Healthy Volunteers Diazepam rectal gel (Diastat®) is the only FDA-approved product indicated for acute repetitive seizures. Despite…webdev2013年8月1日
Brain Extracellular γ-hydroxybutyrate Concentrations are Decreased by L-lactate in Rats: Role in the Treatment of Overdoses Publication Brain Extracellular γ-hydroxybutyrate Concentrations are Decreased by L-lactate in Rats: Role in the Treatment of Overdoses L-lactate represents a potential treatment for GHB overdose by inhibiting GHB renal reabsorption mediated by…webdev2013年5月1日
Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data Publication Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data This article reports an analysis that aims to quantify the effect of fingolimod, an oral…webdev2013年3月1日
Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology Publication Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology The nerve growth factor (NGF) pathway is of great interest as a potential source of…webdev2013年2月21日
Bioavailability of Intranasal vs. Rectal Diazepam Publication Bioavailability of Intranasal vs. Rectal Diazepam There remains an unmet medical need in the out-of-hospital management of seizure emergencies because older…webdev2013年2月1日
Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain Publication Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain A significant barrier to realization of the full potential of clozapine as a therapeutic agent…webdev2012年10月1日
Armodafinil and Modafinil in Patients with Excessive Sleepiness Associated with Shift Work Disorder: A Pharmacokinetic and Pharmacodynamic Model for Predicting and Comparing Their Concentration-effect Relationships Publication Armodafinil and Modafinil in Patients with Excessive Sleepiness Associated with Shift Work Disorder: A Pharmacokinetic and Pharmacodynamic Model for Predicting and Comparing Their Concentration-effect Relationships Armodafinil, the longer lasting R-isomer of racemic modafinil, improves wakefulness in patients with excessive sleepiness…webdev2012年9月1日
Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis Publication Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis Lesion count observed on brain magnetic resonance imaging scan is a common end point in…webdev2012年9月1日