Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis
Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…
Certara2015年5月1日
A Model-based Dose-response Meta-analysis of Ocular Hypotensive Agents as a Drug Development Tool to Evaluate New Therapies in Glaucoma
PURPOSE: To characterize dose and response for intraocular pressure (IOP) reduction and incidence of hyperemia…
Certara2015年5月1日
Time Course of Bone Mineral Density Changes with Denosumab Compared with Other Drugs in Postmenopausal Osteoporosis: A Dose-response-based Meta-analysis
Our objective was to compare the time course of bone mineral density (BMD) changes at…
Certara2014年10月1日
Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients
Model-based meta-analysis of dose response is a sophisticated method to guide dose and regimen selection.…
Certara2014年5月21日
A Model-based Meta-analysis to Compare Efficacy and Tolerability of Tramadol and Tapentadol for the Treatment of Chronic Non-malignant Pain
Pain is a major symptom in many medical conditions which can be relieved thanks to…
Certara2014年2月13日
Using Historical Control Information for the Design and Analysis of Clinical Trials with Overdispersed Count Data
Results from clinical trials are never interpreted in isolation. Previous studies in a similar setting…
Certara2013年9月1日
Clinical Trial Simulation to Inform Phase 2: Comparison of Concentrated vs. Distributed First-in-patient Study Designs in Psoriasis
Clinical trial simulation (CTS) and model-based meta-analysis (MBMA) can increase our understanding of small, first-in-patient…
Certara2013年7月24日
Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects with Type 2 Diabetes Mellitus
The G-protein-coupled receptor 40 agonist (GPR40) TAK-875 is being developed as an adjunct to diet…
Certara2013年1月9日
Placebo Response Changes Depending on the Neuropathic Pain Syndrome: Results of a Systematic Review and Meta-analysis
The purpose of this study was to compare placebo responses in neuropathic pain syndromes through systematic…
Certara2012年4月1日
Model-based Meta-analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond
High development cost, low development success, cost-disciplined health-care policies, and intense competition demand an efficient…
Certara2011年12月1日
