Population Pharmacokinetic Analysis of Thrombomodulin Alfa to Support Dosing Rationale in Patients with Renal Impairment
Thrombomodulin alfa is a soluble recombinant human thrombomodulin that was reported to enhance the reversal…
webdev2015年5月1日
Month 2 Culture Status and Treatment Duration as Predictors of Recurrence in Pulmonary Tuberculosis: Model Validation and Update
New regimens capable of shortening tuberculosis treatment without increasing the risk of recurrence are urgently…
webdev2015年4月29日
Effect of Age and Sex on the Pharmacokinetics and Safety of Avibactam in Healthy Volunteers
Avibactam is a novel non-β-lactam β-lactamase inhibitor currently being assessed in combination with ceftazidime, ceftaroline…
webdev2015年4月1日
Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Avibactam Alone and in Combination with Ceftazidime in Healthy Male Volunteers: Results of Two Randomized, Placebo-controlled Studies
Avibactam is a novel non-β-lactam β-lactamase inhibitor effective against Ambler class A, C and some…
webdev2015年3月27日
Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on…
webdev2015年2月15日
Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects with Varying Degrees of Renal Function and Patients with Bacterial Infections
Ceftolozane/tazobactam is a novel antipseudomonal cephalosporin and a β-lactamase inhibitor in clinical development for treatment…
webdev2015年2月1日
Pharmacokinetics of Injectable, Long-acting Nevirapine for HIV Prophylaxis in Breastfeeding Infants
Mother-to-child transmission (MTCT) of HIV-1 remains a global health problem. The World Health Organization (WHO…
webdev2015年1月1日
Pharmacokinetics of Vancomycin in Critically Ill Patients in Thailand
The pharmacokinetics and pharmacodynamics of drugs in critically ill patients are difficult to predict due…
webdev2014年12月1日
