The Effect of Plasmapheresis on Blood Pressure in Voluntary Plasma Donors
Donor plasmapheresis involves the removal of a weight-adjusted volume of plasma and the return of…
webdev2015年1月1日
Population Dose-response Analysis of Daily Seizure Count Following Vigabatrin Therapy in Adult and Pediatric Patients with Refractory Complex Partial Seizures
Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T) and is used as an…
webdev2015年1月1日
Pharmacokinetics of Injectable, Long-acting Nevirapine for HIV Prophylaxis in Breastfeeding Infants
Mother-to-child transmission (MTCT) of HIV-1 remains a global health problem. The World Health Organization (WHO…
webdev2015年1月1日
Onartuzumab with or without Bevacizumab in Combination with Weekly Paclitaxel Does Not Prolong QTc or Adversely Affect Other ECG Parameters in Patients with Locally Recurrent or Metastatic Triple-negative Breast Cancer
The purpose of this study was to examine the potential effect of onartuzumab, when administered…
webdev2014年12月17日
Meropenem in Children Receiving Continuous Renal Replacement Therapy: Clinical Trial Simulations Using Realistic Covariates
Meropenem is frequently prescribed in children receiving continuous renal replacement therapy (CRRT). Fluid overload is…
webdev2014年12月1日
Vigabatrin Pediatric Dosing Information for Refractory Complex Partial Seizures: Results from a Population Dose-response Analysis
We predicted vigabatrin dosages for adjunctive therapy for pediatric patients with refractory complex partial seizures…
webdev2014年12月1日
Modeling and Simulation for Medical Product Development and Evaluation: Highlights from the FDA-C-Path-ISOP 2013 Workshop
Medical-product development has become increasingly challenging and resource-intensive. In 2004, the Food and Drug Administration…
webdev2014年12月1日
Applications of Linking PBPK and PD Models to Predict the Impact of Genotypic Variability, Formulation Differences, Differences in Target Binding Capacity and Target Site Drug Concentrations on Drug Responses and Variability
This study aimed to demonstrate the added value of integrating prior in vitro data and…
webdev2014年11月26日
Population Pharmacokinetics Analysis of Vigabatrin in Adults and Children with Epilepsy and Children with Infantile Spasms
Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase. The purpose of these analyses was to…
webdev2014年11月1日
