Model Informed Drug Development Archives

Publication

Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression

Objective: Taspine, isolated from Radix et Rhizoma Leonticis has demosntrated potential proctiective effects against cancer.…

Certara2012年1月1日

Publication

Preliminary Comparison of Sertraline Levels in Postbariatric Surgery Patients Versus Matched Non-surgical Cohort

Roux-en-Y gastric bypass (RYGB) is the most frequent bariatric procedure performed in the United States,…

Certara2012年1月1日

Publication

Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite

Clopidogrel is an antiplatelet agent widely used in cardiovascular diseases and an inactive prodrug that…

Certara2012年1月1日

Publication

Application of PBPK Modeling in Drug Discovery and Development at Pfizer

Early prediction of human pharmacokinetics (PK) and drug-drug interactions (DDI) in drug discovery and development…

Certara2012年1月1日

Publication

γ-hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters

The drug of abuse γ-hydroxybutyrate (GHB) displays nonlinear renal clearance, which has been attributed to…

Certara2012年1月1日

Publication

ST Analysis of the Fetal Electrocardiogram in Intrapartum Fetal Monitoring: A Meta-analysis

The objective of this study was to compare the effects of ST-waveform analysis in combination…

Certara2012年1月1日

Publication

Exposure-response Relationship of AMG 386 in Combination with Weekly Paclitaxel in Recurrent Ovarian Cancer and Its Implication for Dose Selection

The purpose of this study was to characterize exposure–response relationships of AMG 386 in a…

Certara2012年1月1日

Publication

Pre-clinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics

The preclinical absorption, distribution, metabolism, and excretion (ADME) properties of Pracinostat -1H-benzimidazol-5-yl]-N-hydroxyarylamide hydrochloride; SB939], an…

Certara2011年12月1日

Publication

Influence of Mild and Moderate Hepatic Impairment on Axitinib Pharmacokinetics

To evaluate the effects of hepatic impairment on the pharmacokinetics and safety of a single,…

Certara2011年12月1日

Publication

Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans

The pharmacokinetics of ibuprofen were studied under microgravity (µG) conditions and compared with those at…

Certara2011年12月1日

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モデルに基づく医薬品開発

Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression

Preliminary Comparison of Sertraline Levels in Postbariatric Surgery Patients Versus Matched Non-surgical Cohort

Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite

Application of PBPK Modeling in Drug Discovery and Development at Pfizer

γ-hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters

ST Analysis of the Fetal Electrocardiogram in Intrapartum Fetal Monitoring: A Meta-analysis

Exposure-response Relationship of AMG 386 in Combination with Weekly Paclitaxel in Recurrent Ovarian Cancer and Its Implication for Dose Selection

Pre-clinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics

Influence of Mild and Moderate Hepatic Impairment on Axitinib Pharmacokinetics

Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans

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