A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology, and Genetics: A Tale of “Bottom-up” vs. “Top-down” Recognition of Covariates Publication A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology, and Genetics: A Tale of “Bottom-up” vs. “Top-down” Recognition of Covariates An increasing number of failures in clinical stages of drug development have been related to…Certara2009年2月28日
Mechanism-based Inhibition of Cytochrome P450 Enzymes: An Evaluation of Early Decision-making In Vitro Approaches and Drug-drug Interaction Prediction Methods Publication Mechanism-based Inhibition of Cytochrome P450 Enzymes: An Evaluation of Early Decision-making In Vitro Approaches and Drug-drug Interaction Prediction Methods The ability to use in vitro human cytochrome P450 (CYP) time-dependent inhibition (TDI) data for in vivo drug-drug interaction (DDI) predictions should be viewed as…Certara2009年2月15日
The Simcyp Population-based ADME Simulator Publication The Simcyp Population-based ADME Simulator The Simcyp® population-based absorption, distribution, metabolism and excretion simulator is a platform and database for…Certara2009年2月6日
Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients Publication Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients What is already known about this subject The use of intravenous pantoprazole, a proton pump…Certara2009年2月1日
Metabolism of Dextrorphan by CYP2D6 in Different Recombinantly Expressed Systems and Its Implications for the In Vitro Assessment of Dextromethorphan Metabolism Publication Metabolism of Dextrorphan by CYP2D6 in Different Recombinantly Expressed Systems and Its Implications for the In Vitro Assessment of Dextromethorphan Metabolism Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used…Certara2009年2月1日
Covariation of Human Microsomal Protein per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling Publication Covariation of Human Microsomal Protein per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling Scaling of metabolic clearance values from liver microsomal data or recombinantly expressed cytochrome P450 enzymes…Certara2008年12月1日
Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential Publication Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential AIMS: To characterize the cytochrome P450 enzyme(s) responsible for the N-dealkylation of maraviroc in vitro,…Certara2008年10月1日
Integrating Systems Approaches into Pharmaceutical Sciences Publication Integrating Systems Approaches into Pharmaceutical Sciences During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and…Certara2008年9月2日
Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability Publication Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability This is a summary report of the EUFEPS & COST B25 conference on Bioavailability and…Certara2008年8月1日
Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain Publication Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain The aim of this study was to develop a pain relief model for a cyclooxygenase…Certara2008年7月1日