Towards a Quantitative Framework for the Prediction of DDIs Arising from Cytochrome P450 Induction Publication Towards a Quantitative Framework for the Prediction of DDIs Arising from Cytochrome P450 Induction Although CYP induction is not generally considered to be as clinically relevant as CYP inhibition,…Certara2009年5月1日
In Vitro and In Vivo Glucuronidation of Midazolam in Humans Publication In Vitro and In Vivo Glucuronidation of Midazolam in Humans Midazolam (MDZ) is a benzodiazepine used as a CYP3A4 probe in clinical and in vitro studies. A…Certara2009年4月1日
Bioavailability and Tolerability of Intranasal Diazepam in Healthy Adult Volunteers Publication Bioavailability and Tolerability of Intranasal Diazepam in Healthy Adult Volunteers Intranasal therapy has been proposed as an alternative for the management of seizure emergencies. The…Certara2009年4月1日
Utilization of Estimated Physicochemical Properties as an Integrated Part of Predicting Hepatic Clearance in the Early Drug-discovery Stage: Impact of Plasma and Microsomal Binding Publication Utilization of Estimated Physicochemical Properties as an Integrated Part of Predicting Hepatic Clearance in the Early Drug-discovery Stage: Impact of Plasma and Microsomal Binding Rapid prediction of hepatic clearance for drug candidates plays an important role for decision-making in…Certara2009年3月1日
Discovery DMPK: Changing Paradigms in the Eighties, Nineties, and Noughties Publication Discovery DMPK: Changing Paradigms in the Eighties, Nineties, and Noughties Background: The science of drug metabolism and pharmacokinetics (DMPK) plays a critical role in supporting…Certara2009年3月1日
Enhancement of Oral Bioavailability of Insulin in Humans Publication Enhancement of Oral Bioavailability of Insulin in Humans OBJECTIVE:The purpose of this study is to investigate oral absorption of 1, 2 and 3…Certara2009年3月1日
Quantitative Evaluation of Pharmacokinetic Inhibition of CYP3A Substrates by Ketoconazole: A Simulation Study Publication Quantitative Evaluation of Pharmacokinetic Inhibition of CYP3A Substrates by Ketoconazole: A Simulation Study The US Food and Drug Administration draft drug interaction guidance recommends that 400 mg ketoconazole (KTZ) be…Certara2009年3月1日
A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology, and Genetics: A Tale of “Bottom-up” vs. “Top-down” Recognition of Covariates Publication A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology, and Genetics: A Tale of “Bottom-up” vs. “Top-down” Recognition of Covariates An increasing number of failures in clinical stages of drug development have been related to…Certara2009年2月28日
Mechanism-based Inhibition of Cytochrome P450 Enzymes: An Evaluation of Early Decision-making In Vitro Approaches and Drug-drug Interaction Prediction Methods Publication Mechanism-based Inhibition of Cytochrome P450 Enzymes: An Evaluation of Early Decision-making In Vitro Approaches and Drug-drug Interaction Prediction Methods The ability to use in vitro human cytochrome P450 (CYP) time-dependent inhibition (TDI) data for in vivo drug-drug interaction (DDI) predictions should be viewed as…Certara2009年2月15日
The Simcyp Population-based ADME Simulator Publication The Simcyp Population-based ADME Simulator The Simcyp® population-based absorption, distribution, metabolism and excretion simulator is a platform and database for…Certara2009年2月6日