A Mechanistic Framework for In Vitro-In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug-drug Interaction Between Rosuvastatin and Cyclosporine Publication A Mechanistic Framework for In Vitro-In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug-drug Interaction Between Rosuvastatin and Cyclosporine The interplay between liver metabolizing enzymes and transporters is a complex process involving system-related parameters such as liver blood perfusion…Certara2013年7月24日
A Randomised Study of the Effect of Danoprevir/Ritonavir or Ritonavir on Substrates of Cytochrome P450 (CYP) 3A and 2C9 in Chronic Hepatitis C Patients Using a Drug Cocktail Publication A Randomised Study of the Effect of Danoprevir/Ritonavir or Ritonavir on Substrates of Cytochrome P450 (CYP) 3A and 2C9 in Chronic Hepatitis C Patients Using a Drug Cocktail Certara2013年7月20日
Model-based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development Publication Model-based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development The pharmaceutical industry continues to face significant challenges. Very few compounds that enter development reach…Certara2013年7月1日
Intravenous Topiramate: Safety and Pharmacokinetics Following a Single Dose in Patients with Epilepsy or Migraines Taking Oral Topiramate Publication Intravenous Topiramate: Safety and Pharmacokinetics Following a Single Dose in Patients with Epilepsy or Migraines Taking Oral Topiramate Although topiramate is widely prescribed for epilepsy and migraine, there is no intravenous product. We…Certara2013年6月1日
Intravenous Topiramate: Comparison of Pharmacokinetics and Safety with the Oral Formulation in Healthy Volunteers Publication Intravenous Topiramate: Comparison of Pharmacokinetics and Safety with the Oral Formulation in Healthy Volunteers Although oral topiramate (TPM) products are widely prescribed for migraines and epilepsy, injectable TPM is not available…Certara2013年6月1日
Characterizing Systemic Exposure of Inhaled Drugs: Application to the Long-acting β2-agonist PF-00610355 Publication Characterizing Systemic Exposure of Inhaled Drugs: Application to the Long-acting β2-agonist PF-00610355 PF-00610355 is an orally inhaled long-acting β2-adrenoreceptor agonist that is being developed for the once-daily…Certara2013年6月1日
Brain Extracellular γ-hydroxybutyrate Concentrations are Decreased by L-lactate in Rats: Role in the Treatment of Overdoses Publication Brain Extracellular γ-hydroxybutyrate Concentrations are Decreased by L-lactate in Rats: Role in the Treatment of Overdoses L-lactate represents a potential treatment for GHB overdose by inhibiting GHB renal reabsorption mediated by…Certara2013年5月1日
Model-based Drug Development in Oncology: What’s Next? 論文 Model-based Drug Development in Oncology: What’s Next? Model-based estimates of tumor growth inhibition (TGI) metrics have the potential to enhance learning in…Certara2013年4月1日
Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide Publication Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide CS-8635, a fixed-dose triple combination of olmesartan, amlodipine, and hydrochlorothiazide, was developed to address the…Certara2013年4月1日
Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body BlogKnowledge Base Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body When I first began learning about pharmacokinetics, I was often confused by the mean residence…Certara2013年3月28日