Model-based Drug Development in Oncology: What’s Next?
Model-based estimates of tumor growth inhibition (TGI) metrics have the potential to enhance learning in…
Certara2013年4月1日
Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide
CS-8635, a fixed-dose triple combination of olmesartan, amlodipine, and hydrochlorothiazide, was developed to address the…
Certara2013年4月1日
Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body
When I first began learning about pharmacokinetics, I was often confused by the mean residence…
Certara2013年3月28日
Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis
Axitinib is a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2,…
Certara2013年3月28日
What is a Loading Dose?
Drug therapy in chronic disease situations requires systemic drug levels to reach target steady-state levels…
Certara2013年3月22日
The Superposition Principle
Discover the superposition principle and its significance in science and mathematics. Learn how this fundamental…
Certara2013年3月14日
Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups
Cerebral white matter (WM) injury and stroke are common neuropathological injuries in newborns with congenital…
Certara2013年3月1日
Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data
This article reports an analysis that aims to quantify the effect of fingolimod, an oral…
Certara2013年3月1日
Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox
Although smallpox has been eradicated, the United States government considers it a "material threat" and…
Certara2013年3月1日
Saturable Drug Absorption
Drug absorption is the process by which a drug molecule moves from the site of…
Certara2013年2月26日
