Modeling and Simulation - PK/PD Archives | Page 27 of 37

Publication

Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis

Axitinib is a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2,…

Certara2013年3月28日

Blog Knowledge Base

What is a Loading Dose?

Drug therapy in chronic disease situations requires systemic drug levels to reach target steady-state levels…

Certara2013年3月22日

Knowledge Base

The Superposition Principle

Discover the superposition principle and its significance in science and mathematics. Learn how this fundamental…

Certara2013年3月14日

Publication

Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups

Cerebral white matter (WM) injury and stroke are common neuropathological injuries in newborns with congenital…

Certara2013年3月1日

Publication

Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data

This article reports an analysis that aims to quantify the effect of fingolimod, an oral…

Certara2013年3月1日

Publication

Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox

Although smallpox has been eradicated, the United States government considers it a "material threat" and…

Certara2013年3月1日

Knowledge Base

Saturable Drug Absorption

Drug absorption is the process by which a drug molecule moves from the site of…

Certara2013年2月26日

Blog Knowledge Base

Nonlinear PK: What Does That Mean?

You may come across a phrase like the following and wonder what it means: “……

Certara2013年2月17日

Knowledge Base

Why Cmax is a Continuous Variable and Tmax is a Categorical Variable

The maximum observed concentration (Cmax) and the time of Cmax (tmax) are both obtained directly…

Certara2013年2月11日

技術情報

What is Quantification Anyway?

Bioanalytical analysis is a fundamental tool for the pharmacokineticist. The results of a bioanalysis are…

Certara2013年2月5日

Modeling and Simulation – PK/PD

Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis

What is a Loading Dose?

The Superposition Principle

Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups

Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data

Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox

Saturable Drug Absorption

Nonlinear PK: What Does That Mean?

Why Cmax is a Continuous Variable and Tmax is a Categorical Variable

What is Quantification Anyway?

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