Modeling and Simulation - PK/PD Archives | Page 30 of 38

Publication

Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis

Lesion count observed on brain magnetic resonance imaging scan is a common end point in…

Certara2012年9月1日

Publication

Saliva Versus Plasma Pharmacokinetics, Theory and Application of a Salivary Excretion Classification System

The aims of this work were to study pharmacokinetics of randomly selected drugs in plasma…

Certara2012年8月1日

Publication

Impact of Low-dose Ritonavir on Danoprevir Pharmacokinetics: Results of Computer-based Simulations and a Clinical Drug-drug Interaction Study

Danoprevir, a potent, selective inhibitor of the hepatitis C virus (HCV) NS3/4A protease, is metabolized…

Certara2012年7月1日

Publication

Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients with Atrial Fibrillation or Atrial Flutter

Vernakalant hydrochloride is a novel, predominantly atrial-selective antiarrhythmic drug that effectively and rapidly terminates atrial…

Certara2012年7月1日

Publication

Pharmacokinetics, Lymph Node Uptake and Mechanistic PK Model of Near Infrared Dye Labeled Bevacizumab After IV and SC Administration in Mice

Our objective was to determine the pharmacokinetics, bioavailability and lymph node uptake of the monoclonal…

Certara2012年6月1日

Publication

Target-mediated Pharmacokinetic and Pharmacodynamic Model of Exendin-4 in Rats, Monkeys, and Humans

A mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) model was developed for exendin-4 to account for receptor-mediated endocytosis via…

Certara2012年5月1日

Publication

Modeling and Simulation of Edoxaban Exposure and Response Relationships in Patients with Atrial Fibrillation

Edoxaban is a novel, orally available, highly specific direct inhibitor of factor Xa and is…

Certara2012年5月1日

Publication

Placebo Response Changes Depending on the Neuropathic Pain Syndrome: Results of a Systematic Review and Meta-analysis

The purpose of this study was to compare placebo responses in neuropathic pain syndromes through systematic…

Certara2012年4月1日

Publication

Population Pharmacokinetic Model for a Novel Oral Hypoglycemic Formed In Vivo: Comparing the Use of Active Metabolite Data Alone Versus Using Data of Upstream and Downstream Metabolites

The purpose of this analysis was to develop a population pharmacokinetic model for CS-917, an…

Certara2012年3月1日

Publication

Brain Uptake of the Drug of Abuse Gamma-hydroxybutyric Acid in Rats

γ-Hydroxybutyric acid (GHB) is an endogenous compound and a substrate for the ubiquitous monocarboxylate transporter…

Certara2012年1月1日

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Modeling and Simulation – PK/PD

Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis

Saliva Versus Plasma Pharmacokinetics, Theory and Application of a Salivary Excretion Classification System

Impact of Low-dose Ritonavir on Danoprevir Pharmacokinetics: Results of Computer-based Simulations and a Clinical Drug-drug Interaction Study

Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients with Atrial Fibrillation or Atrial Flutter

Pharmacokinetics, Lymph Node Uptake and Mechanistic PK Model of Near Infrared Dye Labeled Bevacizumab After IV and SC Administration in Mice

Target-mediated Pharmacokinetic and Pharmacodynamic Model of Exendin-4 in Rats, Monkeys, and Humans

Modeling and Simulation of Edoxaban Exposure and Response Relationships in Patients with Atrial Fibrillation

Placebo Response Changes Depending on the Neuropathic Pain Syndrome: Results of a Systematic Review and Meta-analysis

Population Pharmacokinetic Model for a Novel Oral Hypoglycemic Formed In Vivo: Comparing the Use of Active Metabolite Data Alone Versus Using Data of Upstream and Downstream Metabolites

Brain Uptake of the Drug of Abuse Gamma-hydroxybutyric Acid in Rats

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