What is Curve Stripping?
The process of curve stripping is used in both compartmental and non-compartmental analysis. Each pharmacokinetic…
Certara2011年7月6日
Pharmacokinetic-pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-induced Arthritis
The purpose of this study was to develop a pharmacokinetic-pharmacodynamic disease progression (PK/PD/DIS) model to…
Certara2011年7月1日
Clinical Tolerance and Toxicity of Intravenous Baclofen: A Pilot Study in a Canine Model
Assess safety and tolerance of intravenous (IV) baclofen using a dog model. Prospective pharmacokinetic study…
Certara2011年7月1日
Model-based Development of Anacetrapib, a Novel Cholesteryl Ester Transfer Protein Inhibitor
A model-based strategy was used to inform the early clinical development of anacetrapib, a novel…
Certara2011年6月1日
Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-experienced and CCR5 Antagonist-naive Patients
TBR-652 is a novel CCR5 antagonist with potent in vitro anti-HIV activity. The objective of…
Certara2011年4月12日
What to Do with Those BLQs!
BLQ values are like those pimples we used to get as teenagers. They…
Certara2011年4月6日
The Difference Between Vd and Vss
There are many terms used to represent volume of distribution, but two common ones are…
Certara2011年3月31日
What is Shrinkage?
In 2007, Mats Karlsson and Radojka Savic published a perspective in Clinical Pharmacology & Therapeutics…
Certara2011年3月29日
Is a Monte Carlo Simulation an Exotic Drink?
The term “Monte Carlo simulation” is often used in the modeling and simulation literature with…
Certara2011年3月21日
What is WinNonlin?
A reader suggested that I write a similar post about WinNonlin. Great idea! Thank you!…
Certara2011年3月16日
