Modeling and Simulation - PK/PD Archives | Page 32 of 37

Publication

Clinical Tolerance and Toxicity of Intravenous Baclofen: A Pilot Study in a Canine Model

Assess safety and tolerance of intravenous (IV) baclofen using a dog model. Prospective pharmacokinetic study…

Certara2011年7月1日

Publication

Model-based Development of Anacetrapib, a Novel Cholesteryl Ester Transfer Protein Inhibitor

A model-based strategy was used to inform the early clinical development of anacetrapib, a novel…

Certara2011年6月1日

Publication

Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-experienced and CCR5 Antagonist-naive Patients

TBR-652 is a novel CCR5 antagonist with potent in vitro anti-HIV activity. The objective of…

Certara2011年4月12日

Blog Knowledge Base

What to Do with Those BLQs!

BLQ values are like those pimples we used to get as teenagers. They…

Certara2011年4月6日

Blog Knowledge Base

The Difference Between Vd and Vss

There are many terms used to represent volume of distribution, but two common ones are…

Certara2011年3月31日

技術情報

What is Shrinkage?

In 2007, Mats Karlsson and Radojka Savic published a perspective in Clinical Pharmacology & Therapeutics…

Certara2011年3月29日

技術情報

Is a Monte Carlo Simulation an Exotic Drink?

The term “Monte Carlo simulation” is often used in the modeling and simulation literature with…

Certara2011年3月21日

技術情報

What is WinNonlin?

A reader suggested that I write a similar post about WinNonlin. Great idea! Thank you!…

Certara2011年3月16日

技術情報

What is the Difference Between Individual and Population PK?

Pharmacokinetic analysis is often broken into two areas … “PK” and “population PK”. Sometimes the…

Certara2011年3月14日

技術情報

Blood or Plasma? Which Should You Assay for Drug Concentration?

Explore blood vs. plasma drug concentration assays. Learn their differences, relationships, and impact on accurate…

Certara2011年2月19日

Modeling and Simulation – PK/PD

Clinical Tolerance and Toxicity of Intravenous Baclofen: A Pilot Study in a Canine Model

Model-based Development of Anacetrapib, a Novel Cholesteryl Ester Transfer Protein Inhibitor

Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-experienced and CCR5 Antagonist-naive Patients

What to Do with Those BLQs!

The Difference Between Vd and Vss

What is Shrinkage?

Is a Monte Carlo Simulation an Exotic Drink?

What is WinNonlin?

What is the Difference Between Individual and Population PK?

Blood or Plasma? Which Should You Assay for Drug Concentration?

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