Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation
The aim of this study was to develop a pain relief model for a cyclooxygenase…
Certara2006年4月1日
Model-based Development of Gemcabene, a New Lipid-altering Agent
The purpose of this study was to evaluate the value of model-based, quantitative decision making…
Certara2005年10月7日
Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model
Ciclesonide is a novel and effective inhaled corticosteroid for the treatment of asthma that is…
Certara2005年9月1日
Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation
A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…
Certara2005年9月1日
Modelling Approaches to Dose Estimation in Children
Most of the drugs on the market are originally developed for adults and dosage selection…
Certara2005年6月1日
Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients
Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly…
Certara2005年1月1日
Pharmacokinetics of Dibutylphthalate in Pregnant Rats
Dibutylphthalate (DBP) can cause adverse effects on the developing male reproductive tract when administered late…
Certara2004年12月1日
The Use of Clinical Trial Simulation to Support Dose Selection: Application to Development of a New Treatment for Chronic Neuropathic Pain
Pregabalin is being evaluated for the treatment of neuropathic pain. Two phase 2 studies were…
Certara2003年11月1日
Pharmacokinetics of Melagatran and the Effect on Ex Vivo Coagulation Time in Orthopedic Surgery Patients Receiving Subcutaneous Melagatran and Oral Ximelagatran: A Population Model Analysis
Ximelagatran, an oral direct thrombin inhibitor, is rapidly bioconverted to melagatran, its active form. The…
Certara2003年1月1日
Combining Drug-disease and Economic Modeling to Inform Drug Development Decisions
Drug-disease models and clinical trial simulations are increasingly being used to support trial design and…
Certara2001年11月1日
