Derivation for Logarithmic Trapezoidal AUC Calculation
Calculating area under the curve requires the use of two separate equations: one is follows…
Nathan Teuscher2015年8月5日
100 Articles That Will Help You Understand PBPK Modeling & Simulation
As a company with a strong academic foundation, our scientists actively publish the results of…
Certara2015年7月28日
Population Pharmacokinetic Modeling of Motesanib and Its Active Metabolite, M4, in Cancer Patients
Motesanib is a small molecule and potent multikinase inhibitor with antiangiogenic and antitumor activity. Population…
Danielle Pillsbury2015年7月23日
How to Revamp Your Approach to Conventional IVIVC Models
An IVIVC (in vitro-in vivo correlation) is a predictive mathematical model describing the relationship between…
Certara2015年7月21日
Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance Using a QconCAT Technique
Transporter proteins expressed in the gastrointestinal tract play a major role in the oral absorption of some…
Danielle Pillsbury2015年6月10日
Prediction of Voriconazole Non-linear Pharmacokinetics Using a Pediatric Physiologically-based Pharmacokinetic Modeling Approach
We read with interest the report by Zane and Thakker entitled ‘‘A PBPK model for…
Danielle Pillsbury2015年5月1日
Population Pharmacokinetic Analysis of Thrombomodulin Alfa to Support Dosing Rationale in Patients with Renal Impairment
Thrombomodulin alfa is a soluble recombinant human thrombomodulin that was reported to enhance the reversal…
Danielle Pillsbury2015年5月1日
Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis
Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…
Danielle Pillsbury2015年5月1日
A Model-based Dose-response Meta-analysis of Ocular Hypotensive Agents as a Drug Development Tool to Evaluate New Therapies in Glaucoma
PURPOSE: To characterize dose and response for intraocular pressure (IOP) reduction and incidence of hyperemia…
Danielle Pillsbury2015年5月1日
