Month 2 Culture Status and Treatment Duration as Predictors of Recurrence in Pulmonary Tuberculosis: Model Validation and Update Publication Month 2 Culture Status and Treatment Duration as Predictors of Recurrence in Pulmonary Tuberculosis: Model Validation and Update New regimens capable of shortening tuberculosis treatment without increasing the risk of recurrence are urgently…Danielle Pillsbury2015年4月29日
Pediatric Drug Dosing: Tackling Big Problems for Little Patients Blog 小児への投薬用量:小さな患者のための大きな問題への取り組み 小児薬開発における課題とその複雑さは、広く認識されています。Pharmacometric modeling and simulation (M&S)…Certara2015年4月23日
Effect of Age and Sex on the Pharmacokinetics and Safety of Avibactam in Healthy Volunteers Publication Effect of Age and Sex on the Pharmacokinetics and Safety of Avibactam in Healthy Volunteers Avibactam is a novel non-β-lactam β-lactamase inhibitor currently being assessed in combination with ceftazidime, ceftaroline…Danielle Pillsbury2015年4月1日
Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 Publication Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low…Danielle Pillsbury2015年3月31日
Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Avibactam Alone and in Combination with Ceftazidime in Healthy Male Volunteers: Results of Two Randomized, Placebo-controlled Studies Publication Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Avibactam Alone and in Combination with Ceftazidime in Healthy Male Volunteers: Results of Two Randomized, Placebo-controlled Studies Avibactam is a novel non-β-lactam β-lactamase inhibitor effective against Ambler class A, C and some…Danielle Pillsbury2015年3月27日
Pharmacokinetics and Safety of Oseltamivir in Patients with End-stage Renal Disease Treated with Automated Peritoneal Dialysis Publication Pharmacokinetics and Safety of Oseltamivir in Patients with End-stage Renal Disease Treated with Automated Peritoneal Dialysis Danielle Pillsbury2015年3月25日
Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys Publication 第2期ヒトアフリカトリパノソーマ症の化学療法:非経口ジアミジンDB829と当剤の経口のプロドラッグであるDB868とのベルベットモンキーにおける比較 Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on…Danielle Pillsbury2015年2月15日
Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects with Varying Degrees of Renal Function and Patients with Bacterial Infections Publication Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects with Varying Degrees of Renal Function and Patients with Bacterial Infections Ceftolozane/tazobactam is a novel antipseudomonal cephalosporin and a β-lactamase inhibitor in clinical development for treatment…Danielle Pillsbury2015年2月1日
Common Misconceptions About Computer System Validation Blog Common Misconceptions About Computer System Validation Drug development professionals frequently use computer systems to help them understand the pharmacokinetics (PK) and…Certara2015年1月28日
Using Modeling and Simulation to Quantify the PK of an Anti-HIV Drug for Babies Blog Using Modeling and Simulation to Quantify the PK of an Anti-HIV Drug for Babies As a scientist at Certara and proud Dad to my three kids, pediatric drug development…Certara2015年1月15日