pre-update Archives

Publication

Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

To date, there has been little investigation of the risk for drug-drug interactions involving monoclonal…

Certara2012年9月1日

Publication

Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation

Polycyclic aromatic hydrocarbons (PAHs) in cigarette smoke are among the most likely causes of lung…

Certara2012年9月1日

Publication

Armodafinil and Modafinil in Patients with Excessive Sleepiness Associated with Shift Work Disorder: A Pharmacokinetic and Pharmacodynamic Model for Predicting and Comparing Their Concentration-effect Relationships

Armodafinil, the longer lasting R-isomer of racemic modafinil, improves wakefulness in patients with excessive sleepiness…

Certara2012年9月1日

Publication

Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis

Lesion count observed on brain magnetic resonance imaging scan is a common end point in…

Certara2012年9月1日

Publication

Dose Correction for the Michaelis-Menten Approximation of the Target—Mediated Drug Disposition Model

The Michaelis-Menten (M-M) approximation of the target-mediated drug disposition (TMDD) pharmacokinetic (PK) model was derived…

Certara2012年8月23日

Publication

The Right Compound in the Right Assay at the Right Time: An Integrated Discovery DMPK Strategy

The high rate of attrition during drug development and its associated high research and development…

Certara2012年8月1日

Publication

Saliva Versus Plasma Pharmacokinetics, Theory and Application of a Salivary Excretion Classification System

The aims of this work were to study pharmacokinetics of randomly selected drugs in plasma…

Certara2012年8月1日

Publication

Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-induced Inflammation in Rats

Increased expression of inducible nitric oxide synthase (iNOS) resulting in nitric oxide elevation represents an…

Certara2012年8月1日

Publication

γ-hydroxybutyrate (GHB)-induced Respiratory Depression: Combined Receptor-transporter Inhibition Therapy for Treatment in GHB Overdose

Overdose of & γ;-hydroxybutyrate (GHB) frequently causes respiratory depression, occasionally resulting in death; however, little…

Certara2012年8月1日

Publication

Impact of Low-dose Ritonavir on Danoprevir Pharmacokinetics: Results of Computer-based Simulations and a Clinical Drug-drug Interaction Study

Danoprevir, a potent, selective inhibitor of the hepatitis C virus (HCV) NS3/4A protease, is metabolized…

Certara2012年7月1日

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pre-update

Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation

Armodafinil and Modafinil in Patients with Excessive Sleepiness Associated with Shift Work Disorder: A Pharmacokinetic and Pharmacodynamic Model for Predicting and Comparing Their Concentration-effect Relationships

Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis

Dose Correction for the Michaelis-Menten Approximation of the Target—Mediated Drug Disposition Model

The Right Compound in the Right Assay at the Right Time: An Integrated Discovery DMPK Strategy

Saliva Versus Plasma Pharmacokinetics, Theory and Application of a Salivary Excretion Classification System

Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-induced Inflammation in Rats

γ-hydroxybutyrate (GHB)-induced Respiratory Depression: Combined Receptor-transporter Inhibition Therapy for Treatment in GHB Overdose

Impact of Low-dose Ritonavir on Danoprevir Pharmacokinetics: Results of Computer-based Simulations and a Clinical Drug-drug Interaction Study

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