Are There Differences in the Catalytic Activity per Unit Enzyme of Recombinantly Expressed and Human Liver Microsomal Cytochrome P4502C9? A Systematic Investigation into Inter-system Extrapolation Factors Publication Are There Differences in the Catalytic Activity per Unit Enzyme of Recombinantly Expressed and Human Liver Microsomal Cytochrome P4502C9? A Systematic Investigation into Inter-system Extrapolation Factors The 'relative activity factor' (RAF) compares the activity per unit of microsomal protein in recombinantly…Certara2011年9月1日
Effects of the Moderate CYP3A4 Inhibitor, Fluconazole, on the Pharmacokinetics of Fesoterodine in Healthy Subjects Publication Effects of the Moderate CYP3A4 Inhibitor, Fluconazole, on the Pharmacokinetics of Fesoterodine in Healthy Subjects Available data suggest that fesoterodine dosage should not exceed 4 mg once daily when taken…Certara2011年8月1日
In Vitro-In Vivo Extrapolation of CYP2C8-catalyzed Paclitaxel 6a-hydroxylation: Effects of Albumin on In Vitro Kinetic Parameters and Assessment of Interindividual Variability in Predicted Clearance Publication In Vitro-In Vivo Extrapolation of CYP2C8-catalyzed Paclitaxel 6a-hydroxylation: Effects of Albumin on In Vitro Kinetic Parameters and Assessment of Interindividual Variability in Predicted Clearance This study aimed to characterize the effects of bovine serum albumin (BSA) on the kinetics…Certara2011年8月1日
Ammonia Control in Children with Urea Cycle Disorders (UCDs); Phase 2 Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate Publication Ammonia Control in Children with Urea Cycle Disorders (UCDs); Phase 2 Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate Twenty four hour ammonia profiles and correlates of drug effect were examined in a phase…Certara2011年8月1日
How Can PK/PD Analysis Add Value to Patient Care? 技術情報 How Can PK/PD Analysis Add Value to Patient Care? In May 2011, T.J. Smith and B.E. Hillner published an opinion piece in the New…Certara2011年7月11日
What is Curve Stripping? 技術情報 What is Curve Stripping? The process of curve stripping is used in both compartmental and non-compartmental analysis. Each pharmacokinetic…Certara2011年7月6日
Pharmacokinetic-pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-induced Arthritis Publication Pharmacokinetic-pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-induced Arthritis The purpose of this study was to develop a pharmacokinetic-pharmacodynamic disease progression (PK/PD/DIS) model to…Certara2011年7月1日
Clinical Tolerance and Toxicity of Intravenous Baclofen: A Pilot Study in a Canine Model Publication Clinical Tolerance and Toxicity of Intravenous Baclofen: A Pilot Study in a Canine Model Assess safety and tolerance of intravenous (IV) baclofen using a dog model. Prospective pharmacokinetic study…Certara2011年7月1日
Simulation of Clinical Drug-drug Interactions from Hepatocyte CYP3A4 Induction Data and Its Potential Utility in Trial Designs Publication Simulation of Clinical Drug-drug Interactions from Hepatocyte CYP3A4 Induction Data and Its Potential Utility in Trial Designs Rifampin and carbamazepine have been recommended in the U.S. Food and Drug Administration draft drug…Certara2011年7月1日
Metabolism of [D10]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration Publication Metabolism of [D10]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration Polycyclic aromatic hydrocarbons (PAHs) are believed to be among the causative agents for lung cancer…Certara2011年7月1日