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In Vitro and In Silico Identification and Characterization of Thiabendazole as a Mechanism-based Inhibitor of CYP1A2 and Simulation of Possible Pharmacokinetic Drug-drug Interactions Publication

In Vitro and In Silico Identification and Characterization of Thiabendazole as a Mechanism-based Inhibitor of CYP1A2 and Simulation of Possible Pharmacokinetic Drug-drug Interactions

Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2.…
Certara
2009年6月1日
Utilization of Estimated Physicochemical Properties as an Integrated Part of Predicting Hepatic Clearance in the Early Drug-discovery Stage: Impact of Plasma and Microsomal Binding Publication

Utilization of Estimated Physicochemical Properties as an Integrated Part of Predicting Hepatic Clearance in the Early Drug-discovery Stage: Impact of Plasma and Microsomal Binding

Rapid prediction of hepatic clearance for drug candidates plays an important role for decision-making in…
Certara
2009年3月1日
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