The Simcyp Population-based ADME Simulator
The Simcyp® population-based absorption, distribution, metabolism and excretion simulator is a platform and database for…
Certara2009年2月6日
Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients
What is already known about this subject The use of intravenous pantoprazole, a proton pump…
Certara2009年2月1日
Metabolism of Dextrorphan by CYP2D6 in Different Recombinantly Expressed Systems and Its Implications for the In Vitro Assessment of Dextromethorphan Metabolism
Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used…
Certara2009年2月1日
More Than Numbers: The Power of Graphs in Meta-analysis
In meta-analysis, the assessment of graphs is widely used in an attempt to identify or…
Certara2009年1月15日
Pharmacokinetic Predictions in Children by Using the Physiologically-based Pharmacokinetic Modeling
Nowadays, 50-90% of drugs used in children have never been actually studied in this population. Consequently, either…
Certara2008年12月1日
Covariation of Human Microsomal Protein per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling
Scaling of metabolic clearance values from liver microsomal data or recombinantly expressed cytochrome P450 enzymes…
Certara2008年12月1日
Pharmacokinetics, Safety, and Tolerability of Teduglutide, a Glucagon-like Peptide-2 (GLP-2) Analog, Following Multiple Ascending Subcutaneous Administrations in Healthy Subjects
Teduglutide, a glucagon-like peptide-2 (GLP-2) analog, is currently being evaluated for the treatment of short-bowel…
Certara2008年11月1日
Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential
AIMS: To characterize the cytochrome P450 enzyme(s) responsible for the N-dealkylation of maraviroc in vitro,…
Certara2008年10月1日
Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery
Stroke after cardiac surgery may be caused by emboli emerging from an atherosclerotic ascending aorta…
Certara2008年10月1日
Accurate and Interpretable Computational Modeling of Chemical Mutagenicity
We describe a method for modeling chemical mutagenicity in terms of simple rules based on…
Certara2008年9月5日
