Integrating Systems Approaches into Pharmaceutical Sciences
During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and…
Certara2008年9月2日
Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability
This is a summary report of the EUFEPS & COST B25 conference on Bioavailability and…
Certara2008年8月1日
A Novel Druglike Spleen Tyrosine Kinase Binder Prevents Anaphylactic Shock when Administered Orally
BACKGROUND: The spleen tyrosine kinase (Syk) is recognized as a potential pharmaceutical target for the…
Certara2008年7月1日
Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease
The presence of cytochrome P450 enzymes in the small bowel results in the reduced bioavailability…
Certara2008年7月1日
Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain
The aim of this study was to develop a pain relief model for a cyclooxygenase…
Certara2008年7月1日
A Phospho-sugar Binding Domain Homologous to NagB Enzymes Regulates the Activity of the Central Glycolytic Genes Repressor
CggR belongs to the SorC family of bacterial transcriptional regulators which control the expression of…
Certara2008年6月1日
In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions
It is widely accepted that today's practice of polypharmacy inevitably increases the incidence of drug-drug…
Certara2008年6月1日
Integrated In Vitro Analysis for the In Vivo Prediction of Cytochrome P450-mediated Drug-drug Interactions
Unbound IC50 (IC50,u) values of 15 drugs were determined in eight recombinantly expressed human cytochromes P450…
Certara2008年6月1日
Application of CYP3A4 In Vitro Data to Predict Clinical Drug-drug Interactions: Predictions of Compounds as Objects of Interaction
Numerous retrospective analyses have shown the utility of in vitro systems for predicting potential drug-drug interactions (DDIs). Prediction of DDIs…
Certara2008年5月1日
Development of CYP2D6 and CYP3A4 in the First Year of Life
Recently, Blake et al . ‘‘Ontogeny of dextromethorphan O- and N-demethylation in the first year…
Certara2008年5月1日
